IQGAP2 - IQ motif containing GTPase activating protein 2 Gene

Homo sapiens

Gene ID: 10788 | Gene type: protein coding

About IQGAP2

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,403,285-76,708,132 (from NCBI)

This gene has 21 transcripts (splice variants), 209 orthologues and 2 paralogues. Broad expression in liver (RPKM 36.3), duodenum (RPKM 28.2) and 21 other tissues.

Summary

This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the Cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate Antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

IQGAP2 Products(4)

mRNA	Protein	Name
NM_001285460.2	NP_001272389.2	ras GTPase-activating-like protein IQGAP2 isoform 2
NM_001285461.2	NP_001272390.2	ras GTPase-activating-like protein IQGAP2 isoform 3
NM_001285462.2	NP_001272391.2	ras GTPase-activating-like protein IQGAP2 isoform 4
NM_006633.5	NP_006624.3	ras GTPase-activating-like protein IQGAP2 isoform 1

IQGAP2 Protein Structure

RasGAP

RasGAP_C

0
300
600
900
1200
1575 a.a.

Protein Preferred Names

Protein Names

ras GTPase-activating-like protein IQGAP2

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 64

DFNA64	Autosomal Dominant Nonsyndromic Deafness 64
Autosomal Dominant Deafness 64	Deafness, Autosomal Dominant, 64
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 64	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 64
Deafness, Autosomal Dominant, Type 64

Lethal Restrictive Dermopathy

Hyperkeratosis-Contracture Syndrome	Tight Skin Contracture Syndrome
Tight Skin Contracture Syndrome, Lethal	Dermopathy, Restrictive, Lethal

Enchondromatosis, Multiple, Ollier Type

Ollier Disease	Enchondromatosis
Dyschondroplasia	Osteochondromatosis
Multiple Cartilaginous Enchondroses	Multiple Enchondromatosis
Enchondromatosis With Haemangiomata	Enchondromatosis, Multiple
Kast'S Syndrome	Ollier'S Syndrome
Enchondromatosis Multiple	ENCHOM
Maffucci Disease	Olliers Disease
Hereditary Multiple Exostoses	Chondromatosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06886	IQGAP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IQGAP2	VGNC	VGNC:30259
Canis familiaris	IQGAP2	VGNC	VGNC:42082
Mus musculus	IQGAP2	MGD	MGI:2449975
Macaca mulatta	IQGAP2	VGNC	VGNC:73756
Rattus norvegicus	IQGAP2	RGD	RGD:2321734
Felis catus	IQGAP2	VGNC	VGNC:67818

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