Xrcc4 - X-ray repair complementing defective repair in Chinese hamster cells 4 Gene

Mus musculus

Also known as 2310057B22Rik

Gene ID: 108138 | Gene type: protein coding

About Xrcc4

Summary

Contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in double-strand break repair via nonhomologous end joining; negative regulation of protection from non-homologous end joining at telomere; and telomeric DNA-containing double minutes formation. Acts upstream of or within several processes, including DNA metabolic process; hemopoiesis; and nervous system development. Located in chromosome, telomeric region. Part of DNA-dependent protein kinase-DNA Ligase 4 complex and ERCC4-ERCC1 complex. Is expressed in head; heart; and trunk. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human XRCC4 (X-ray repair cross complementing 4). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc4 Products(1)

mRNA	Protein	Name
NM_028012.4	NP_082288.1	DNA repair protein XRCC4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to 3' overhang single-stranded DNA endodeoxyribonuclease activity	IMP IMP: Inferred from mutant phenotype	14690602	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DN2 thymocyte differentiation	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within DNA ligation	IDA IDA: Inferred from direct assay	15194694	MGI
acts upstream of or within V(D)J recombination	IMP IMP: Inferred from mutant phenotype	10716994	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	17713479	MGI
involved in double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	14690602	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within immunoglobulin V(D)J recombination	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within isotype switching	IMP IMP: Inferred from mutant phenotype	17713479	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9875844	MGI
involved in negative regulation of protection from non-homologous end joining at telomere	IMP IMP: Inferred from mutant phenotype	14690602	MGI
acts upstream of neurogenesis	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within response to X-ray	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	9875844	MGI
acts upstream of or within response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	17713479	MGI
involved in telomeric DNA-containing double minutes formation	IMP IMP: Inferred from mutant phenotype	14690602	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA-dependent protein kinase-DNA ligase 4 complex	IDA IDA: Inferred from direct assay	15194694	MGI
part of ERCC4-ERCC1 complex	IDA IDA: Inferred from direct assay	14690602	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	14690602	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA repair protein XRCC4

X-ray repair cross-complementing protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15899	XRCC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118273	IPS-05002	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xrcc4	NCBI	NCBI:7518

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