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  3. ADCY3 - adenylate cyclase 3 Gene

ADCY3 - adenylate cyclase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AC3; AC-III; BMIQ19

Gene ID: 109 | Gene type: protein coding

About ADCY3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,819,169-24,920,237 (from NCBI)

This gene has 13 transcripts (splice variants), 264 orthologues, 17 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 27.7), ovary (RPKM 14.8) and 23 other tissues.

Summary

This gene encodes adenylyl cyclase 3 which is a membrane-associated Enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ADCY3 Products(7)

mRNA Protein Name
NM_001320613.2 NP_001307542.1 adenylate cyclase type 3 isoform 1
NM_001377128.1 NP_001364057.1 adenylate cyclase type 3 isoform 3
NM_001377129.1 NP_001364058.1 adenylate cyclase type 3 isoform 4
NM_001377130.1 NP_001364059.1 adenylate cyclase type 3 isoform 5
NM_001377131.1 NP_001364060.1 adenylate cyclase type 3 isoform 6
NM_001377132.1 NP_001364061.1 adenylate cyclase type 3 isoform 2
NM_004036.5 NP_004027.2 adenylate cyclase type 3 isoform 2

ADCY3 Protein Structure

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (311 - 472)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (915 - 1120)

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  • 1144 a.a.
Protein Preferred Names Protein Names

adenylate cyclase type 3

ATP pyrophosphate-lyase 3

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 19

Obesity

BMIQ19

Obesity, Susceptibility To

Obesity, Susceptibility To, Bmiq19

Obesity Bmiq19

{Obesity, Susceptibility To, Bmiq19}
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Amelogenesis Imperfecta, Type Iiic

AI3C

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive

Amelogenesis Imperfecta Type 3c

Amelogenesis Imperfecta, Type 3c

Amelogenesis Imperfecta Type Iiic

Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3c
Central Corneal Ulcer
Joubert Syndrome 24

JBTS24
Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2

CPVT2

Vtsip

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Ventricular Tachycardia, Stress-Induced Polymorphic

Cvpt2

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation
Capillary Malformations, Congenital

Familial Multiple Nevi Flammei

Nevi Flammei, Familial Multiple

CMC

Port-Wine Stain

Capillary Malformations

Cmal

Familial Multiple Port-Wine Stains

Capillary Malformation

Capillary Malformations, Congenital, 1, Somatic, Mosaic

Congenital Capillary Malformations

Port-Wine Stain Familial Multiple

Hereditary Capillary Malformations

Capillary Malformations, Hereditary

Capillary Malformations, Congenital, Type 1, Somatic, Mosaic

Strawberry Nevus Of Skin

Naevus Flammeus
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00329 ADCY3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADCY3 VGNC VGNC:37620
Mus musculus ADCY3 MGD MGI:99675
Macaca mulatta ADCY3 VGNC VGNC:69511
Felis catus ADCY3 VGNC VGNC:59616
Bos taurus ADCY3 VGNC VGNC:25644
Rattus norvegicus ADCY3 RGD RGD:71009