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Ank2 - ankyrin 2, brain Gene

Also Known as Ank-2; Gm4392; 100043364

Species: Mus musculus

Gene Type: protein coding

Gene ID: 109676

Summary

Enables several functions, including ATPase binding activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; regulation of cardiac muscle cell action potential; and regulation of heart contraction. Acts upstream of or within several processes, including cardiac muscle contraction; regulation of cardiac muscle cell membrane potential; and regulation of cation channel activity. Located in several cellular components, including T-tubule; intercalated disc; and myofibril. Is integral component of plasma membrane. Is active in paranodal junction. Is expressed in central nervous system; eye; genitourinary system; and heart. Used to study sinoatrial node disease. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Ank2 Products (4)

mRNA	Protein	Name
NM_001034168.1	NP_001029340.1	ankyrin-2 isoform 3
NM_001327938.1	NP_001314867.1	ankyrin-2 isoform 4
NM_001327939.1	NP_001314868.1	ankyrin-2 isoform 5
NM_178655.3	NP_848770.2	ankyrin-2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	16292983	MGI
enables potassium channel regulator activity	IMP IMP: Inferred from mutant phenotype	20610380	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15262991	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	16292983	MGI
enables protein-macromolecule adaptor activity	IMP IMP: Inferred from mutant phenotype	20610380	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16292983	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in SA node cell action potential	IMP IMP: Inferred from mutant phenotype	18832177	MGI
involved in SA node cell to atrial cardiac muscle cell communication	IMP IMP: Inferred from mutant phenotype	18832177	MGI
acts upstream of or within T-tubule organization	IMP IMP: Inferred from mutant phenotype	20610380	MGI
involved in T-tubule organization	IMP IMP: Inferred from mutant phenotype	16292983	MGI
involved in atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	21859974	MGI
involved in atrial cardiac muscle cell to AV node cell communication	IMP IMP: Inferred from mutant phenotype	12571597	MGI
acts upstream of or within cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	15262991	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	18832177	MGI
involved in positive regulation of calcium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18832177	MGI
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	18832177	MGI
involved in positive regulation of cation channel activity	IMP IMP: Inferred from mutant phenotype	19805355	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17242276	MGI
involved in positive regulation of potassium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	19805355	MGI
involved in positive regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	19805355	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	15262991	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	17242276	MGI
involved in protein localization to M-band	IMP IMP: Inferred from mutant phenotype	15262991	MGI
involved in protein localization to T-tubule	IMP IMP: Inferred from mutant phenotype	16292983	MGI
involved in protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	15262991	MGI
involved in protein localization to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	11781319	MGI
acts upstream of or within protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	20489164	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20489164	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	18832177	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17178715	MGI
involved in regulation of AV node cell action potential	IMP IMP: Inferred from mutant phenotype	12571597	MGI
involved in regulation of SA node cell action potential	IMP IMP: Inferred from mutant phenotype	12571597	MGI
involved in regulation of atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	12571597	MGI
involved in regulation of calcium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21859974	MGI
involved in regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	12571597	MGI
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	17242276	MGI
acts upstream of or within regulation of cardiac muscle cell membrane potential	IGI IGI: Inferred from genetic interaction	20489164	MGI
acts upstream of or within regulation of cardiac muscle cell membrane potential	IMP IMP: Inferred from mutant phenotype	20489164	MGI
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	15178757	MGI
involved in regulation of cardiac muscle contraction by calcium ion signaling	IMP IMP: Inferred from mutant phenotype	12571597	MGI
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP IMP: Inferred from mutant phenotype	17178715	MGI
acts upstream of or within regulation of cation channel activity	IMP IMP: Inferred from mutant phenotype	20610380	MGI
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	18832177	MGI
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	11781319	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in A band	IDA IDA: Inferred from direct assay	11781319	MGI
located in M band	IDA IDA: Inferred from direct assay	12571597	MGI
located in M band	IMP IMP: Inferred from mutant phenotype	21859974	MGI
located in T-tubule	IDA IDA: Inferred from direct assay	12571597	MGI
located in Z disc	IDA IDA: Inferred from direct assay	11781319	MGI
located in costamere	IDA IDA: Inferred from direct assay	16292983	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15262991	MGI
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	19007774	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	12571597	MGI
is active in paranodal junction	IDA IDA: Inferred from direct assay	16687515	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20489164	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20489164	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18832177	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	16292983	MGI
located in sarcolemma	IMP IMP: Inferred from mutant phenotype	21859974	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ankyrin-2	ankyrin-B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00700	ANK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ank2	NCBI	NCBI:287