Hyal3 - hyaluronoglucosaminidase 3 Gene

Mus musculus

Also known as Hyl3

Gene ID: 109685 | Gene type: protein coding

About Hyal3

Summary

Enables hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; negative regulation of ovarian follicle development; and ovarian follicle atresia. Located in cytoplasmic vesicle; endoplasmic reticulum; and sperm midpiece. Is expressed in several structures, including cardiovascular system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human HYAL3 (hyaluronidase 3). [provided by Alliance of Genome Resources, Apr 2022]

Hyal3 Products(1)

mRNA	Protein	Name
NM_178020.3	NP_821139.2	hyaluronidase-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables hyalurononglucosaminidase activity	IDA IDA: Inferred from direct assay	18234732	MGI
enables hyalurononglucosaminidase activity	IDA IDA: Inferred from direct assay	20586096	MGI
NOT enables virus receptor activity	IDA IDA: Inferred from direct assay	11296287	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in hyaluronan catabolic process	IDA IDA: Inferred from direct assay	20586096	MGI
involved in negative regulation of ovarian follicle development	IDA IDA: Inferred from direct assay	18653706	MGI
involved in ovarian follicle atresia	IDA IDA: Inferred from direct assay	18653706	MGI
involved in penetration of zona pellucida	IMP IMP: Inferred from mutant phenotype	20586096	MGI
involved in positive regulation of acrosomal vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	20586096	MGI
involved in response to virus	IDA IDA: Inferred from direct assay	11296287	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal membrane	IDA IDA: Inferred from direct assay	20586096	MGI
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	20586096	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	18234732	MGI
located in early endosome	IDA IDA: Inferred from direct assay	18234732	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18234732	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	20586096	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hyaluronidase-3

hyal-3

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991212	Berahyaluronidase alfa	Degrader	99.01%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06497	HYAL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13628	SPAM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hyal3	NCBI	NCBI:8372

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