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Cat. No.: HY-P991212

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Berahyaluronidase alfa

(Synonyms: ALT-B4)

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Based on 1 Customer Validation

Berahyaluronidase alfa (ALT-B4) is a recombinant hyaluronidase engineered from human hyaluronidase PH20. Berahyaluronidase alfa features favorable structural stability and enzymatic activity, and can be used to enhance drug absorption and dispersion in subcutaneous or intradermal administration.

For research use only. We do not sell to patients.

Purity: 99.01%
CAS No.: 2636716-20-4
Molecular Weight:50.06 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Berahyaluronidase alfa Chemical Structure

CAS No.: 2636716-20-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Berahyaluronidase alfa demonstrates favorable safety and tolerability and can be administered subcutaneously^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2636716-20-4
Appearance Liquid
Molecular Weight 50.06 kDa
Color Colorless to off-white
SMILES

[Berahyaluronidase alfa]
Synonyms

ALT-B4
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Kopp-Kubel S. International Nonproprietary Names (INN) for pharmaceutical substances. Bull World Health Organ. 1995;73(3):275-9.

[2]. Torras O R, et al. Abstract CT036: Bioavailability of MK-3475A (pembrolizumab with berahyaluronidase alfa;“subcutaneous pembrolizumab”) in participants with advanced or metastatic solid tumors[J]. Cancer Research, 2025, 85(8_Supplement_2): CT036-CT036

[3]. Lee JS, et al. The Safety, Tolerability, and Pharmacokinetics of ALT-BB4 (A Novel Recombinant Hyaluronidase): A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study in Healthy Volunteers. Dermatol Ther (Heidelb). 2025 Nov;15(11):3301-3311. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
- Clinical Trial
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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Berahyaluronidase alfa

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Antibody Inhibitor Library

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Berahyaluronidase alfa Related Classifications

HY-P991212 Related Classifications