2636716-20-4
2636716-20-4
Chemical Structure
Berahyaluronidase alfa
Synonym(s): ALT-B4
- CAS No.: 2636716-20-4
- Formula:N/A
- Molecular Weight:(50.06 kDa)
SMILES: [Berahyaluronidase alfa]
Biological Activity: Berahyaluronidase alfa (ALT-B4) is a recombinant hyaluronidase engineered from human hyaluronidase PH20. Berahyaluronidase alfa features favorable structural stability and enzymatic activity, and can be used to enhance drug absorption and dispersion in subcutaneous or intradermal administration[1][2][3].
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Berahyaluronidase alfa | 99.01% | Berahyaluronidase alfa (ALT-B4) is a recombinant hyaluronidase engineered from human hyaluronidase PH20. Berahyaluronidase alfa features favorable structural stability and enzymatic activity, and can be used to enhance drug absorption and dispersion in subcutaneous or intradermal administration. | ||||||||||||||||||||
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References
- [1]. Kopp-Kubel S. International Nonproprietary Names (INN) for pharmaceutical substances. Bull World Health Organ. 1995;73(3):275-9.
- [2]. Torras O R, et al. Abstract CT036: Bioavailability of MK-3475A (pembrolizumab with berahyaluronidase alfa;“subcutaneous pembrolizumab”) in participants with advanced or metastatic solid tumors[J]. Cancer Research, 2025, 85(8_Supplement_2): CT036-CT036
- [3]. Lee JS, et al. The Safety, Tolerability, and Pharmacokinetics of ALT-BB4 (A Novel Recombinant Hyaluronidase): A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study in Healthy Volunteers. Dermatol Ther (Heidelb). 2025 Nov;15(11):3301-3311. [Content Brief]
Keywords
