2. Gene
  3. Dync2h1 - dynein cytoplasmic 2 heavy chain 1 Gene

Dync2h1 - dynein cytoplasmic 2 heavy chain 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DHC2; DHC11; DHC1b; Dnchc2; mDHC11; m152Asp; m407Asp; b2b414Clo; 4432416O06Rik; D030010H02Rik; D330044F14Rik

Gene ID: 110350 | Gene type: protein coding

About Dync2h1

Summary

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within several processes, including animal organ development; cilium organization; and positive regulation of smoothened signaling pathway. Located in apical part of cell; axoneme; and motile cilium. Is expressed in brain ventricular layer and olfactory epithelium. Used to study VACTERL association and asphyxiating thoracic dystrophy 3. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 3. Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]

Dync2h1 Products(2)

mRNA Protein Name
NM_001364519.1 NP_001351448.1 cytoplasmic dynein 2 heavy chain 1 isoform 2
NM_029851.3 NP_084127.2 cytoplasmic dynein 2 heavy chain 1 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
16061793 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
15755804 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
21552265 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
15755804 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
16229832 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16229832 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within intraciliary retrograde transport IMP
IMP: Inferred from mutant phenotype
18488998 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
21552265 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
22689656 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
18488998 MGI
acts upstream of or within protein localization to cilium IMP
IMP: Inferred from mutant phenotype
16229832 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
16061793 MGI
acts upstream of or within spinal cord motor neuron differentiation IGI
IGI: Inferred from genetic interaction
21552265 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12802074 MGI
located in axoneme IDA
IDA: Inferred from direct assay
12802074 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
12802074 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic dynein 2 heavy chain 1

cytoplasmic dynein heavy chain 2

dynein heavy chain 11

dynein heavy chain isotype 1B

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04086 DYNC2H1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dync2h1 NCBI NCBI:79659