Slc8a2 - solute carrier family 8 (sodium/calcium exchanger), member 2 Gene

Also Known as Ncx2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110891

Summary

Enables calcium:sodium antiporter activity. Involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Located in axon terminus and postsynaptic density. Is integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex mantle layer; embryo; and olfactory cortex mantle layer. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc8a2 Products (2)

mRNA Protein Name
NM_001347561.1 NP_001334490.1 sodium/calcium exchanger 2 isoform 2 precursor
NM_148946.3 NP_683748.1 sodium/calcium exchanger 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17884163 MGI
enables calcium:sodium antiporter activity IMP
IMP: Inferred from mutant phenotype
12818181 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium ion export across plasma membrane IMP
IMP: Inferred from mutant phenotype
17884163 MGI
involved in calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
12818181 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
27595821 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12818181 MGI
involved in learning IMP
IMP: Inferred from mutant phenotype
12818181 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
29274751 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
12818181 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
12818181 MGI
acts upstream of or within modulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
17884163 MGI
acts upstream of or within positive regulation of protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
29274751 MGI
acts upstream of or within regulation of action potential firing pattern IMP
IMP: Inferred from mutant phenotype
17884163 MGI
acts upstream of regulation of calcineurin-mediated signaling IMP
IMP: Inferred from mutant phenotype
29274751 MGI
acts upstream of or within regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
17884163 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
29274751 MGI
involved in regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
12818181 MGI
acts upstream of or within response to ischemia IMP
IMP: Inferred from mutant phenotype
17884163 MGI
involved in sodium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
12818181 MGI
acts upstream of or within synapse organization IMP
IMP: Inferred from mutant phenotype
29274751 MGI
Cellular Component GO Annotation Evidence References Source
located in axon terminus IMP
IMP: Inferred from mutant phenotype
29274751 MGI
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
12818181 MGI
located in postsynaptic density IMP
IMP: Inferred from mutant phenotype
29274751 MGI
located in synapse IDA
IDA: Inferred from direct assay
29274751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/calcium exchanger 2

  • Na(+)/Ca(2+)-exchange protein 2

  • solute carrier family 8 member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13338 SLC8A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc8a2 NCBI NCBI:6543