Slc8a2 - solute carrier family 8 (sodium/calcium exchanger), member 2 Gene

Mus musculus

Also known as Ncx2

Gene ID: 110891 | Gene type: protein coding

About Slc8a2

Summary

Enables calcium:sodium antiporter activity. Involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Located in axon terminus and postsynaptic density. Is integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex mantle layer; embryo; and olfactory cortex mantle layer. Orthologous to human SLC8A2 (solute carrier family 8 member A2). [provided by Alliance of Genome Resources, Apr 2022]

Slc8a2 Products(2)

mRNA	Protein	Name
NM_001347561.1	NP_001334490.1	sodium/calcium exchanger 2 isoform 2 precursor
NM_148946.3	NP_683748.1	sodium/calcium exchanger 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	17884163	MGI
enables calcium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	12818181	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion export across plasma membrane	IMP IMP: Inferred from mutant phenotype	17884163	MGI
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	12818181	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	27595821	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	12818181	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	12818181	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	29274751	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	12818181	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	12818181	MGI
acts upstream of or within modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	17884163	MGI
acts upstream of or within positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	29274751	MGI
acts upstream of or within regulation of action potential firing pattern	IMP IMP: Inferred from mutant phenotype	17884163	MGI
acts upstream of regulation of calcineurin-mediated signaling	IMP IMP: Inferred from mutant phenotype	29274751	MGI
acts upstream of or within regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	17884163	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	12818181	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	17884163	MGI
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	12818181	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	29274751	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IMP IMP: Inferred from mutant phenotype	29274751	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	12818181	MGI
located in postsynaptic density	IMP IMP: Inferred from mutant phenotype	29274751	MGI
located in synapse	IDA IDA: Inferred from direct assay	29274751	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/calcium exchanger 2

Na(+)/Ca(2+)-exchange protein 2

solute carrier family 8 member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13338	SLC8A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc8a2	NCBI	NCBI:6543

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