SLC8A2 - solute carrier family 8 member A2 Gene

Also Known as NCX2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6543

About SLC8A2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,428,017-47,471,893 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 7 paralogues. Biased expression in brain (RPKM 19.6), endometrium (RPKM 1.5) and 1 other tissue.

Summary

Predicted to enable calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Part of presynapse. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

SLC8A2 Products (1)

mRNA	Protein	Name
NM_015063.3	NP_055878.1	sodium/calcium exchanger 2 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in presynapse	IDA IDA: Inferred from direct assay	21382638	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC8A2 Protein Structure

Na_Ca_ex

Calx-beta

Na_Ca_ex

0
200
400
600
800
921 a.a.

Protein Preferred Names	Protein Names
sodium/calcium exchanger 2	Na(+)/Ca(2+)-exchange protein 2

Related Diseases

Diseases	Alias
Ischemia	Acute Coronary Syndrome
Schnyder Corneal Dystrophy	Schnyder Crystalline Corneal Dystrophy SCCD Corneal Dystrophy, Crystalline, Of Schnyder Corneal Dystrophy, Schnyder Type Corneal Dystrophy Crystalline Of Schnyder Crystalline Stromal Dystrophy Hereditary Crystalline Stromal Dystrophy Of Schnyder Scd Corneal Dystrophy, Schnyder Schnyder Crystalline Dystrophy Sine Crystals Dystrophy, Corneal, Crystalline, Schnyder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13338	SLC8A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC8A2	MGD	MGI:107996
Canis familiaris	SLC8A2	VGNC	VGNC:46481
Rattus norvegicus	SLC8A2	RGD	RGD:620194
Bos taurus	SLC8A2	VGNC	VGNC:34936
Felis catus	SLC8A2	VGNC	VGNC:65429
Macaca mulatta	SLC8A2	VGNC	VGNC:77635
Others	SLC8A2	NCBI