2. Gene
  3. Hlcs - holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) Gene

Hlcs - holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D16Jhu34; 410I21.SP6

Gene ID: 110948 | Gene type: protein coding

About Hlcs

Summary

Predicted to enable biotin binding activity; biotin-protein Ligase activity; and enzyme binding activity. Predicted to be involved in histone biotinylation and response to biotin. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Hlcs Products(4)

mRNA Protein Name
NM_001360045.1 NP_001346974.1 biotin--protein ligase isoform 1
NM_139145.5 NP_631884.1 biotin--protein ligase isoform 2
NM_001360045.1 NP_001346974.1 biotin--protein ligase isoform 1
NM_139145.5 NP_631884.1 biotin--protein ligase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables biotin--[biotin carboxyl-carrier protein] ligase activity IMP
IMP: Inferred from mutant phenotype
35385533 MGI
Biological Process GO Annotation Evidence Reference Source
involved in biotin metabolic process IMP
IMP: Inferred from mutant phenotype
35385533 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

biotin--protein ligase

biotin apo-protein ligase

biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12564 Phthalazinone pyrazole Inhibitor 98.0% Unkown
HY-183354 HLC40 / Unkown
HY-RS06218 HLCS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hlcs NCBI NCBI:3141