2. Gene
  3. ADAMTS8 - ADAM metallopeptidase with thrombospondin type 1 motif 8 Gene

ADAMTS8 - ADAM metallopeptidase with thrombospondin type 1 motif 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as METH2; ADAM-TS8

Gene ID: 11095 | Gene type: protein coding

About ADAMTS8

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:130,404,923-130,428,609 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 25 paralogues. Biased expression in lung (RPKM 12.6), appendix (RPKM 7.0) and 8 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]

ADAMTS8 Products(1)

mRNA Protein Name
NM_007037.6 NP_008968.4 A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein

ADAMTS8 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (47 - 149)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (219 - 429)

TSP_1

TSP_1: Thrombospondin type 1 domain (531 - 580)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (691 - 809)

TSP_1

TSP_1: Thrombospondin type 1 domain (839 - 887)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 889 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 8

ADAMTS-8

Related Diseases

Diseases Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 2

HNPCC2

Fcc2

Coca2

Hereditary Nonpolyposis Colorectal Cancer Type 2

Colon Cancer, Familial Nonpolyposis, Type 2

Familial Nonpolyposis Colon Cancer Type 2

Hereditary Non-Polyposis Colorectal Cancer 2

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 2
Weill-Marchesani Syndrome

Gemss Syndrome

Spherophakia-Brachymorphia Syndrome

Marchesani-Weill Syndrome

Wms

Congenital Mesodermal Dystrophy

Mesodermal Dysmorphodystrophy, Congenital

Spherophakia Brachymorphia Syndrome

Mesodermal Dysmorphodystrophy Congenital

Wm Syndrome

Brachydactyly-Spherophakia Syndrome

Brachymorphy With Spherophakia Syndrome

Congenital Mesodermal Dysmorphodystrophy

Marchesani Syndrome

Weill-Marchesani Syndrome, Autosomal Recessive

Weill-Marchesani Syndrome, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00308 ADAMTS8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADAMTS8 VGNC VGNC:25629
Felis catus ADAMTS8 VGNC VGNC:59597
Macaca mulatta ADAMTS8 VGNC VGNC:69501
Rattus norvegicus ADAMTS8 RGD RGD:1308511
Mus musculus ADAMTS8 MGD MGI:1353468
Canis familiaris ADAMTS8 VGNC VGNC:37604
Others ADAMTS8 NCBI