PWP1 - PWP1 homolog, endonuclein Gene

Also Known as NCLB; IEF-SSP-9502

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11137

About PWP1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:107,685,799-107,713,162 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 14.1), brain (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PWP1 Products (3)

mRNA Protein Name
NM_001317962.2 NP_001304891.1 periodic tryptophan protein 1 homolog isoform 2
NM_001317963.2 NP_001304892.1 periodic tryptophan protein 1 homolog isoform 3
NM_007062.3 NP_008993.1 periodic tryptophan protein 1 homolog isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
IDA: Inferred from direct assay
29065309 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
29065309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PWP1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (253 - 285)

WD40

WD40: WD domain, G-beta repeat (290 - 328)

WD40

WD40: WD domain, G-beta repeat (376 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

periodic tryptophan protein 1 homolog

  • endonuclein

PWP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82039 PWP1 Antibody (YA1784) WB Human
HY-P82039A PWP1 Antibody (YA1784)(PBS only) WB Human

Related Diseases

Diseases Alias
Porokeratosis

  • Disseminated Superficial Actinic Porokeratosis

  • Dsap

  • Porokeratosis Of Mibelli

  • Porokeratosis, Disseminated Superficial Actinic

  • Porokeratosis, Disseminated Superficial Actinic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11475 PWP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PWP1 VGNC VGNC:45215
Bos taurus PWP1 VGNC VGNC:33580
Felis catus PWP1 VGNC VGNC:64442
Mus musculus PWP1 MGD MGI:1914735
Rattus norvegicus PWP1 RGD RGD:1310705
Others PWP1 NCBI