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PWP1 Antibody (YA1784)

(Synonyms: IEF-SSP-9502)

PWP1 Antibody (YA1784) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PWP1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

PWP1 Antibody (YA1784) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PWP1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 75 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 56 kDa
Species Reactivity Database

Entrez Gene: 11137 Human

SwissProt: Q13610 Human

Immunogen

A synthetic peptide of human PWP1

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PWP1 is a Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the epigenetic status of rDNA[1].

  • Subcellular Localization

    Nucleus; Nucleus, nucleolus; Chromosome

  • Expression


    Tissue_specificity:High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung

  • Isoforms & Post-Translational Modification

    Q13610 has 2 isomers: Q13610-1: 55828 Da (predicted); Q13610-2: 16309 Da (predicted).

  • Subunit

    Associates with the RNA polymerase (Pol I) complex (PubMed:29065309). Interacts with POLR1E (PubMed:29065309)

  • SwissProt ID

    Q13610

  • Gene ID
    11137 [NCBI]
  • Synonyms

    IEF-SSP-9502

  • Research Field

    Cell Biology

References

[1]. Liu Y, et al. PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression. Dev Cell. 2017 Oct 23;43(2):240-252.e5. [Content Brief]

PWP1 Antibody (YA1784) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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