TREH - trehalase Gene

Also Known as TRE; TREA; TREHD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11181

About TREH

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,657,316-118,679,650 (from NCBI)

This gene has 5 transcripts (splice variants), 178 orthologues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 44.4), small intestine (RPKM 43.7) and 1 other tissue.

Summary

This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, Plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TREH Products (2)

mRNA Protein Name
NM_001301065.2 NP_001287994.1 trehalase isoform 2 precursor
NM_007180.3 NP_009111.2 trehalase isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha,alpha-trehalase activity IDA
IDA: Inferred from direct assay
8773341 GOA
Biological Process GO Annotation Evidence References Source
involved in trehalose catabolic process IDA
IDA: Inferred from direct assay
9427547 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREH Protein Structure

Trehalase

Trehalase: Trehalase (46 - 551)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

trehalase

  • alpha,alpha-trehalose glucohydrolase

Related Diseases

Diseases Alias
Trehalase Deficiency

  • Trehalose Intolerance

  • Isolated Trehalose Intolerance

  • TREHD

  • Alpha, Alpha-Trehalase Deficiency
Lactase Deficiency, Congenital

  • Congenital Lactase Deficiency

  • Disaccharide Intolerance Ii

  • Congenital Alactasia

  • Congenital Alactasia Syndrome

  • Congenital Lactose Intolerance

  • Congenital Lactose Malabsorption

  • Hereditary Alactasia

  • Alactasia, Congenital

  • Cld

  • COLACD

  • Disaccharide Intolerance Type 2

  • Cld - [Congenital Lactase Deficiency]

  • Disaccharide Intolerance 2

  • Lactose Intolerance Of Newborn

  • Hereditary Lactase Deficiency
Sucrase-Isomaltase Deficiency, Congenital

  • Congenital Sucrase-Isomaltase Deficiency

  • CSID

  • Si Deficiency

  • Congenital Sucrose Intolerance

  • Disaccharide Intolerance

  • Sucrase-Isomaltase Deficiency

  • Disaccharide Intolerance I

  • Congenital Sucrose-Isomaltose Malabsorption

  • Sucrose-Isomaltose Malabsorption, Congenital

  • Sucrose Intolerance, Congenital

  • Congenital Sucrase-Isomaltose Malabsorption

  • Congenital Sucrose-Isomaltase Malabsorption

  • Disaccharide Intolerance, 1

  • Sucrose Intolerance Congenital

  • Sucrose-Isomaltase Malabsorption, Congenital

  • Disaccharidase Deficiency

  • Invertase Deficiency

  • Sucrase-Alpha-Dextrinase Deficiency

  • Disaccharide Intolerance Type I

  • Csid - [Congenital Sucrase-Isomaltase Deficiency]

  • Sucrose Intolerance Of Newborn

  • Sucrose Intolerance

  • Sucrase Deficiency

  • Disaccharide Malabsorption

  • Intestinal Disaccharidase Deficiency
Oligohydramnios

  • Oligohydramnios - Delivered

  • Antepartum Oligohydramnios

  • Delivered Oligohydramnios

  • Oligohydramnios, Antepartum Condition Or Complication

  • Deficient Liquor

  • Oligohydramnios, Unspecified Trimester

  • Reduced Liquor Volume
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15001 TREH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TREH VGNC VGNC:36297
Canis familiaris TREH VGNC VGNC:47792
Rattus norvegicus TREH RGD RGD:61831
Macaca mulatta TREH VGNC VGNC:101418
Mus musculus TREH MGD MGI:1926230
Others TREH NCBI