TREH - trehalase Gene

Homo sapiens

Also known as TRE; TREA; TREHD

Gene ID: 11181 | Gene type: protein coding

About TREH

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,657,316-118,679,650 (from NCBI)

This gene has 5 transcripts (splice variants), 178 orthologues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 44.4), small intestine (RPKM 43.7) and 1 other tissue.

Summary

This gene encodes an Enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, Plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TREH Products(2)

mRNA	Protein	Name
NM_001301065.2	NP_001287994.1	trehalase isoform 2 precursor
NM_007180.3	NP_009111.2	trehalase isoform 1 precursor

TREH Protein Structure

Trehalase

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

trehalase

alpha,alpha-trehalose glucohydrolase

Related Diseases

Diseases

Alias

Trehalase Deficiency

Trehalose Intolerance	Isolated Trehalose Intolerance
TREHD	Alpha, Alpha-Trehalase Deficiency

Lactase Deficiency, Congenital

Congenital Lactase Deficiency	Disaccharide Intolerance Ii
Congenital Alactasia	Congenital Alactasia Syndrome
Congenital Lactose Intolerance	Congenital Lactose Malabsorption
Hereditary Alactasia	Alactasia, Congenital
Cld	COLACD
Disaccharide Intolerance Type 2	Cld - [Congenital Lactase Deficiency]
Disaccharide Intolerance 2	Lactose Intolerance Of Newborn
Hereditary Lactase Deficiency

Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency	CSID
Si Deficiency	Congenital Sucrose Intolerance
Disaccharide Intolerance	Sucrase-Isomaltase Deficiency
Disaccharide Intolerance I	Congenital Sucrose-Isomaltose Malabsorption
Sucrose-Isomaltose Malabsorption, Congenital	Sucrose Intolerance, Congenital
Congenital Sucrase-Isomaltose Malabsorption	Congenital Sucrose-Isomaltase Malabsorption
Disaccharide Intolerance, 1	Sucrose Intolerance Congenital
Sucrose-Isomaltase Malabsorption, Congenital	Disaccharidase Deficiency
Invertase Deficiency	Sucrase-Alpha-Dextrinase Deficiency
Disaccharide Intolerance Type I	Csid - [Congenital Sucrase-Isomaltase Deficiency]
Sucrose Intolerance Of Newborn	Sucrose Intolerance
Sucrase Deficiency	Disaccharide Malabsorption
Intestinal Disaccharidase Deficiency

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15001	TREH Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TREH	VGNC	VGNC:36297
Canis familiaris	TREH	VGNC	VGNC:47792
Rattus norvegicus	TREH	RGD	RGD:61831
Macaca mulatta	TREH	VGNC	VGNC:101418
Mus musculus	TREH	MGD	MGI:1926230
Others	TREH	NCBI