CHRNB3 - cholinergic receptor nicotinic beta 3 subunit Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1142

About CHRNB3

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,697,366-42,737,407 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues and 45 paralogues. Low expression observed in reference dataset.

Summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

CHRNB3 Products (2)

mRNA Protein Name
NM_000749.5 NP_000740.1 neuronal acetylcholine receptor subunit beta-3 isoform 1 precursor
NM_001347717.2 NP_001334646.1 neuronal acetylcholine receptor subunit beta-3 isoform 2

CHRNB3 Protein Structure

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (29 - 232)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (240 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit beta-3

  • acetylcholine receptor, neuronal nicotinic, beta-3 subunit

Recombinant CHRNB3 Proteins

Cat. No. Product Name Accession Purity
HY-P70056 CHRNB3 Protein, Human (HEK293, His) Q05901 (I25-L232) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Duane Retraction Syndrome

  • Stilling-Turk-Duane Syndrome

  • Duane'S Syndrome

  • Duane Syndrome

  • Isolated Duane Retraction Syndrome

  • Co-Contractive Retraction Syndrome

  • Duane Anomaly, Isolated

  • Ocular Retraction Syndrome

  • Drs

  • Durs
Compensatory Emphysema
Dystonia 6, Torsion

  • DYT6

  • Torsion Dystonia 6

  • Dystonia 6

  • Idiopathic Torsion Dystonia Of Mixed Type

  • Primary Dystonia, Dyt6 Type

  • Torsion Dystonia, Adult-Onset, Mixed Type

  • Dyt-Thap1

  • Adolescent-Onset Dystonia Of Mixed Type

  • Torsion Dystonia Adult Onset Mixed Type

  • Dyt6 Dystonia

  • Thap1 Dystonia

  • Generalized Cervical And Upper-Limb-Onset Dystonia

  • Adult-Onset Torsion Dystonia Mixed Type

  • Autosomal Dominant Torsion Dystonia 6

  • Dystonia-6

  • Torsion Dystonia Type 6

  • Dystonia, Type 6, Torsion
Tobacco Addiction

  • Nicotine Dependence

  • Tobacco Addiction, Susceptibility To

  • Nicotine Addiction

  • Tobacco Use Disorder

  • Smoking Habit

  • Nicotine Dependence, Protection Against

  • Nicotine Addiction, Protection From

  • Cigarette Habituation

  • Cigarette Habituation, Susceptibility To

  • Smoking Habit, Susceptibility To

  • Nicotine Dependence, Susceptibility To

  • Nicotine Addiction, Susceptibility To

  • Addiction, Tobacco, Susceptibility To

  • Compulsive Tobacco User Syndrome

  • Tobacco Dependence

  • Tobacco Dependence Syndrome

  • Cigarette Addiction

  • Cigarette Dependence

  • Smoking Addiction

  • Smokers Syndrome
Cocaine Dependence
Substance Dependence
Drug Dependence
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

  • Adnfle

  • Autosomal Dominant Sleep-Related Hypermotor Epilepsy

  • Enfl

  • Benign Familial Infantile Seizures 6

  • Benign Familial Infantile Seizures, 6

  • Nocturnal Frontal Lobe Epilepsy-4

  • Enfl1

  • Epilepsy, Nocturnal Frontal Lobe, 1

  • Epilepsy, Nocturnal Frontal Lobe, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02676 CHRNB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21105 Chrnb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27624 Chrnb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHRNB3 VGNC VGNC:39244
Rattus norvegicus CHRNB3 RGD RGD:621544
Felis catus CHRNB3 VGNC VGNC:60885
Bos taurus CHRNB3 VGNC VGNC:27332
Mus musculus CHRNB3 MGD MGI:106212
Macaca mulatta CHRNB3 VGNC VGNC:104445
Others CHRNB3 NCBI