Npnt - nephronectin Gene

Also Known as Nctn; POEM; 1110009H02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 114249

Summary

Enables Integrin binding activity. Involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of Alkaline Phosphatase activity. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regulation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in basement membrane; extracellular region; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NPNT (nephronectin). [provided by Alliance of Genome Resources, Apr 2022]

Npnt Products (5)

mRNA Protein Name
NM_001029836.2 NP_001025007.1 nephronectin isoform b precursor
NM_001287101.1 NP_001274030.1 nephronectin isoform c precursor
NM_001287102.1 NP_001274031.1 nephronectin isoform d precursor
NM_001287103.1 NP_001274032.1 nephronectin isoform e
NM_033525.3 NP_277060.2 nephronectin isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
19342381 MGI
enables integrin binding IPI
IPI: Inferred from physical interaction
11546798 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
17537792 MGI
involved in cell-cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
19342381 MGI
acts upstream of or within cell-matrix adhesion IDA
IDA: Inferred from direct assay
11470831 MGI
acts upstream of or within cell-matrix adhesion IPI
IPI: Inferred from physical interaction
11470831 MGI
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
21689636 MGI
involved in establishment of protein localization IMP
IMP: Inferred from mutant phenotype
21335239 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: Inferred from direct assay
18757743 MGI
involved in pilomotor reflex IMP
IMP: Inferred from mutant phenotype
21335239 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19944102 MGI
involved in positive regulation of alkaline phosphatase activity IDA
IDA: Inferred from direct assay
19944102 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19944102 MGI
involved in positive regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
21335239 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21335239 MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17537792 MGI
involved in smooth muscle cell differentiation IDA
IDA: Inferred from direct assay
21335239 MGI
acts upstream of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17537792 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
17537792 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
18757743 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
21335239 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
11470831 MGI
located in extracellular matrix IPI
IPI: Inferred from physical interaction
11470831 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
19944102 MGI
located in smooth muscle contractile fiber IDA
IDA: Inferred from direct assay
21335239 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nephronectin

  • preosteoblast EGF-like repeat protein with MAM domain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09493 NPNT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20785 Npnt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27299 Npnt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npnt NCBI NCBI:255743