NPNT - nephronectin Gene

Also Known as POEM; EGFL6L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 255743

About NPNT

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:105,895,471-105,971,671 (from NCBI)

This gene has 16 transcripts (splice variants), 250 orthologues and 1 paralogue. Biased expression in thyroid (RPKM 91.1), lung (RPKM 60.2) and 10 other tissues.

Summary

Predicted to enable Integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; positive regulation of ERK1 and ERK2 cascade; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular exosome. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

NPNT Products (5)

mRNA Protein Name
NM_001033047.3 NP_001028219.1 nephronectin isoform B precursor
NM_001184690.2 NP_001171619.1 nephronectin isoform A precursor
NM_001184691.2 NP_001171620.1 nephronectin isoform C precursor
NM_001184692.2 NP_001171621.1 nephronectin isoform D precursor
NM_001184693.2 NP_001171622.1 nephronectin isoform E precursor

NPNT Protein Structure

EGF_CA

EGF_CA: Calcium-binding EGF domain (89 - 120)

EGF_CA

EGF_CA: Calcium-binding EGF domain (169 - 202)

EGF_CA

EGF_CA: Calcium-binding EGF domain (214 - 253)

MAM

MAM: MAM domain, meprin/A5/mu (422 - 563)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 565 a.a.
Protein Preferred Names Protein Names

nephronectin

  • preosteoblast EGF-like repeat protein with MAM domain

Related Diseases

Diseases Alias
Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities

  • NPHS5

  • Nephrotic Syndrome Type 5

  • Nephrotic Syndrome Type 5, With Or Without Ocular Abnormalities

  • Nephrotic Syndrome 5 With Or Without Ocular Abnormalities

  • Nephrotic Syndrome, Type 5, With/Without Ocular Abnormalities
Renal Hypodysplasia/Aplasia 1

  • Renal Agenesis

  • Renal Adysplasia

  • Renal Aplasia

  • RHDA1

  • Hereditary Renal Aplasia

  • Hra

  • Hereditary Urogenital Adysplasia

  • Hypodysplasia/Aplasia, Renal, Type 1

  • Congenital Absence Of Kidneys Syndrome

  • Congenital Absence Of Kidney

  • Aplastic Kidney
Fibrosarcomatous Osteosarcoma

  • Fibroblastic Osteosarcoma

  • Fibrosarcomatous Osteogenic Sarcoma
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09493 NPNT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20785 Npnt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27299 Npnt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NPNT VGNC VGNC:43924
Macaca mulatta NPNT VGNC VGNC:75266
Mus musculus NPNT MGD MGI:2148811
Bos taurus NPNT VGNC VGNC:32209
Felis catus NPNT VGNC VGNC:63872
Rattus norvegicus NPNT RGD RGD:1593709
Others NPNT NCBI