NPNT - nephronectin Gene

Homo sapiens

Also known as POEM; EGFL6L

Gene ID: 255743 | Gene type: protein coding

About NPNT

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:105,895,471-105,971,671 (from NCBI)

This gene has 16 transcripts (splice variants), 250 orthologues and 1 paralogue. Biased expression in thyroid (RPKM 91.1), lung (RPKM 60.2) and 10 other tissues.

Summary

Predicted to enable Integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; positive regulation of ERK1 and ERK2 cascade; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular exosome. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

NPNT Products(5)

mRNA	Protein	Name
NM_001033047.3	NP_001028219.1	nephronectin isoform B precursor
NM_001184690.2	NP_001171619.1	nephronectin isoform A precursor
NM_001184691.2	NP_001171620.1	nephronectin isoform C precursor
NM_001184692.2	NP_001171621.1	nephronectin isoform D precursor
NM_001184693.2	NP_001171622.1	nephronectin isoform E precursor

NPNT Protein Structure

EGF_CA

MAM

0
100
200
300
400
500
565 a.a.

Protein Preferred Names

Protein Names

nephronectin

preosteoblast EGF-like repeat protein with MAM domain

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities

NPHS5	Nephrotic Syndrome Type 5
Nephrotic Syndrome Type 5, With Or Without Ocular Abnormalities	Nephrotic Syndrome 5 With Or Without Ocular Abnormalities
Nephrotic Syndrome, Type 5, With/Without Ocular Abnormalities

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Fibrosarcomatous Osteosarcoma

Fibroblastic Osteosarcoma

Fibrosarcomatous Osteogenic Sarcoma

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09493	NPNT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NPNT	VGNC	VGNC:43924
Macaca mulatta	NPNT	VGNC	VGNC:75266
Mus musculus	NPNT	MGD	MGI:2148811
Bos taurus	NPNT	VGNC	VGNC:32209
Felis catus	NPNT	VGNC	VGNC:63872
Rattus norvegicus	NPNT	RGD	RGD:1593709