SLC26A7 - solute carrier family 26 member 7 Gene

Also Known as SUT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 115111

About SLC26A7

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:91,209,496-91,398,155 (from NCBI)

This gene has 10 transcripts (splice variants), 139 orthologues and 9 paralogues. Restricted expression toward thyroid (RPKM 194.6).

Summary

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]

SLC26A7 Products (4)

mRNA	Protein	Name
NM_001282356.2	NP_001269285.1	anion exchange transporter isoform a
NM_001282357.2	NP_001269286.1	anion exchange transporter isoform c
NM_052832.4	NP_439897.1	anion exchange transporter isoform a
NM_134266.2	NP_599028.1	anion exchange transporter isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chloride channel activity	IDA IDA: Inferred from direct assay	11834742	GOA
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	12736153	GOA
enables oxalate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11834742	GOA
enables sulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	11834742	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chloride transport	IDA IDA: Inferred from direct assay	11834742	GOA
involved in iodide transport	IMP IMP: Inferred from mutant phenotype	31372509	GOA
involved in oxalate transport	IDA IDA: Inferred from direct assay	11834742	GOA
involved in sulfate transmembrane transport	IDA IDA: Inferred from direct assay	11834742	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	31372509	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	30333321	GOA
located in basolateral plasma membrane	IMP IMP: Inferred from mutant phenotype	16524946	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16524946	GOA
located in endosome	IDA IDA: Inferred from direct assay	16524946	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	31372509	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A7 Protein Structure

Sulfate_transp

STAS

0
200
400
600
656 a.a.

Protein Preferred Names	Protein Names
anion exchange transporter	solute carrier family 26 (anion exchanger), member 7

Related Diseases

Diseases	Alias
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Dyshormonogenic Goiter	Dyshormonogenic Goitre
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Diastrophic Dysplasia	Diastrophic Dwarfism DTD Dd Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant Dysplasia, Diastrophic Diastrophic Dysplasia Variant
Renal Tubular Acidosis	Acidosis Renal Tubular Acidosis, Renal Tubular Lightwood-Albright Syndrome Lightwood Syndrome Idiopathic Infantile Hypercalcemia - Mild Form Kidney Tubular Acidosis Renal Tubule Acidosis Kidney Acidosis Renal Acidosis Renal Hyperchloremic Acidosis Rta - [Renal Tubular Acidosis]
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Brown-Vialetto-Van Laere Syndrome 2	BVVLS2 Rfvt3-Related Riboflavin Transporter Deficiency Rtd3 Riboflavin Transporter Deficiency 3 Brown-Vialetto-Van Laere Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13141	SLC26A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC26A7	MGD	MGI:2384791
Canis familiaris	SLC26A7	VGNC	VGNC:46326
Rattus norvegicus	SLC26A7	RGD	RGD:1310846
Bos taurus	SLC26A7	VGNC	VGNC:34782
Felis catus	SLC26A7	VGNC	VGNC:65285
Macaca mulatta	SLC26A7	VGNC	VGNC:77478
Others	SLC26A7	NCBI