LYPD1 - LY6/PLAUR domain containing 1 Gene

Also Known as PHTS; LYPDC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116372

About LYPD1

Cytogenetic location: 2q21.2 Genomic coordinates (GRCh38): 2:132,643,286-132,671,526 (from NCBI)

This gene has 3 transcripts (splice variants), 249 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.3), colon (RPKM 1.3) and 16 other tissues.

Summary

Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within several processes, including behavioral fear response; cholinergic synaptic transmission; and negative regulation of protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

LYPD1 Products (4)

mRNA Protein Name
NM_001077427.4 NP_001070895.1 ly6/PLAUR domain-containing protein 1 isoform b
NM_001321234.2 NP_001308163.1 ly6/PLAUR domain-containing protein 1 isoform c
NM_001321235.2 NP_001308164.1 ly6/PLAUR domain-containing protein 1 isoform b
NM_144586.7 NP_653187.3 ly6/PLAUR domain-containing protein 1 isoform a precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ly6/PLAUR domain-containing protein 1

  • putative HeLa tumor suppressor

Related Diseases

Diseases Alias
Arthrogryposis, Distal, Type 2a

  • Freeman-Sheldon Syndrome

  • Craniocarpotarsal Dystrophy

  • Craniocarpotarsal Dysplasia

  • DA2A

  • Whistling Face-Windmill Vane Hand Syndrome

  • Fss

  • Distal Arthrogryposis Type 2a

  • Whistling Face Syndrome

  • Freeman-Burian Syndrome

  • Arthrogryposis Distal Type 2a

  • Distal Arthrogryposis, Type 2a

  • Fbs

  • Arthrogryposis, Distal, 2a
Melanotic Medulloblastoma

  • Medulloblastoma, Melanotic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07915 LYPD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LYPD1 RGD RGD:1549754
Macaca mulatta LYPD1 VGNC VGNC:104542
Felis catus LYPD1 VGNC VGNC:63339
Mus musculus LYPD1 MGD MGI:1919835
Canis familiaris LYPD1 VGNC VGNC:42883
Bos taurus LYPD1 VGNC VGNC:31099
Others LYPD1 NCBI