CLTB - clathrin light chain B Gene

Also Known as LCB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1212

About CLTB

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,392,455-176,416,569 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 44.6), skin (RPKM 37.3) and 25 other tissues.

Summary

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CLTB Products (4)

mRNA Protein Name
NM_001364126.3 NP_001351055.1 clathrin light chain B isoform c
NM_001364127.2 NP_001351056.1 clathrin light chain B isoform d
NM_001834.5 NP_001825.1 clathrin light chain B isoform a
NM_007097.5 NP_009028.1 clathrin light chain B isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11889126 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLTB Protein Structure

Clathrin_lg_ch

Clathrin_lg_ch: Clathrin light chain (1 - 227)

  • 0
  • 100
  • 200
  • 229 a.a.
Protein Preferred Names Protein Names

clathrin light chain B

  • clathrin, light chain (Lcb)

Related Diseases

Diseases Alias
Leber Congenital Amaurosis 1

  • LCA1

  • Amaurosis Congenita Of Leber I

  • Lca

  • Retinal Blindness, Congenital

  • Crb

  • Leber Congenital Amaurosis Type I

  • Leber Congenital Amaurosis, Type 1

  • Amaurosis Congenita Of Leber, Type 1
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02844 CLTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLTB MGD MGI:1921575
Rattus norvegicus CLTB RGD RGD:621353
Macaca mulatta CLTB VGNC VGNC:71267
Felis catus CLTB VGNC VGNC:60983
Bos taurus CLTB VGNC VGNC:27470
Canis familiaris CLTB VGNC VGNC:39366
Others CLTB NCBI