CLTB - clathrin light chain B Gene

Homo sapiens

Also known as LCB

Gene ID: 1212 | Gene type: protein coding

About CLTB

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,392,455-176,416,569 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 44.6), skin (RPKM 37.3) and 25 other tissues.

Summary

Clathrin is a large, soluble protein composed of heavy and LIGHT chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin LIGHT chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CLTB Products(4)

mRNA	Protein	Name
NM_001364126.3	NP_001351055.1	clathrin light chain B isoform c
NM_001364127.2	NP_001351056.1	clathrin light chain B isoform d
NM_001834.5	NP_001825.1	clathrin light chain B isoform a
NM_007097.5	NP_009028.1	clathrin light chain B isoform b

CLTB Protein Structure

Clathrin_lg_ch

0
100
200
229 a.a.

Protein Preferred Names

Protein Names

clathrin light chain B

clathrin, light chain (Lcb)

Related Diseases

Diseases

Alias

Leber Congenital Amaurosis 1

LCA1	Amaurosis Congenita Of Leber I
Lca	Retinal Blindness, Congenital
Crb	Leber Congenital Amaurosis Type I
Leber Congenital Amaurosis, Type 1	Amaurosis Congenita Of Leber, Type 1

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02844	CLTB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CLTB	MGD	MGI:1921575
Rattus norvegicus	CLTB	RGD	RGD:621353
Macaca mulatta	CLTB	VGNC	VGNC:71267
Felis catus	CLTB	VGNC	VGNC:60983
Bos taurus	CLTB	VGNC	VGNC:27470
Canis familiaris	CLTB	VGNC	VGNC:39366