ANO4 - anoctamin 4 Gene

Homo sapiens

Also known as TMEM16D

Gene ID: 121601 | Gene type: protein coding

About ANO4

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:100,717,261-101,128,641 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 195 orthologues and 10 paralogues. Biased expression in adrenal (RPKM 3.2), brain (RPKM 1.6) and 5 other tissues.

Summary

Enables intracellular calcium activated Chloride Channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ANO4 Products(3)

mRNA	Protein	Name
NM_001286615.2	NP_001273544.1	anoctamin-4 isoform 1
NM_001286616.1	NP_001273545.1	anoctamin-4 isoform 1
NM_178826.4	NP_849148.2	anoctamin-4 isoform 2

ANO4 Protein Structure

Anoctamin

0
200
400
600
800
955 a.a.

Protein Preferred Names

Protein Names

anoctamin-4

transmembrane protein 16D

Related Diseases

Diseases

Alias

Scott Syndrome

SCTS	Bdplt7
Prothrombin Consumption Deficiency	Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X
Bleeding Disorder, Platelet-Type, 7	Prothrombin Conversion Defect, Familial
Prothrombin Consumption Inhibitor, Familial	Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X
Familial Prothrombin Consumption Inhibitor	Familial Prothrombin Conversion Defect
Platelet-Type Bleeding Disorder 7	Platelet Factor X Receptor Deficiency
Bleeding Disorder Platelet-Type 7	Prothrombin Consumption Inhibitor Familial
Prothrombin Conversion Defect Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00744	ANO4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ANO4	RGD	RGD:1310252
Canis familiaris	ANO4	VGNC	VGNC:37927
Macaca mulatta	ANO4	VGNC	VGNC:69677
Felis catus	ANO4	VGNC	VGNC:82371
Bos taurus	ANO4	VGNC	VGNC:25953
Mus musculus	ANO4	MGD	MGI:2443344