ANO4 - anoctamin 4 Gene

Also Known as TMEM16D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 121601

About ANO4

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:100,717,261-101,128,641 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 195 orthologues and 10 paralogues. Biased expression in adrenal (RPKM 3.2), brain (RPKM 1.6) and 5 other tissues.

Summary

Enables intracellular calcium activated Chloride Channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ANO4 Products (3)

mRNA Protein Name
NM_001286615.2 NP_001273544.1 anoctamin-4 isoform 1
NM_001286616.1 NP_001273545.1 anoctamin-4 isoform 1
NM_178826.4 NP_849148.2 anoctamin-4 isoform 2

ANO4 Protein Structure

Anoctamin

Anoctamin: Calcium-activated chloride channel (339 - 922)

  • 0
  • 200
  • 400
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  • 800
  • 955 a.a.
Protein Preferred Names Protein Names

anoctamin-4

  • transmembrane protein 16D

Related Diseases

Diseases Alias
Scott Syndrome

  • SCTS

  • Bdplt7

  • Prothrombin Consumption Deficiency

  • Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X

  • Bleeding Disorder, Platelet-Type, 7

  • Prothrombin Conversion Defect, Familial

  • Prothrombin Consumption Inhibitor, Familial

  • Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X

  • Familial Prothrombin Consumption Inhibitor

  • Familial Prothrombin Conversion Defect

  • Platelet-Type Bleeding Disorder 7

  • Platelet Factor X Receptor Deficiency

  • Bleeding Disorder Platelet-Type 7

  • Prothrombin Consumption Inhibitor Familial

  • Prothrombin Conversion Defect Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00744 ANO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ANO4 RGD RGD:1310252
Canis familiaris ANO4 VGNC VGNC:37927
Macaca mulatta ANO4 VGNC VGNC:69677
Felis catus ANO4 VGNC VGNC:82371
Bos taurus ANO4 VGNC VGNC:25953
Mus musculus ANO4 MGD MGI:2443344
Others ANO4 NCBI