TDRD9 - tudor domain containing 9 Gene

Also Known as HLS; SPNE; HIG-1; NET54; SPGF30; C14orf75

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 122402

About TDRD9

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,928,456-104,052,667 (from NCBI)

This gene has 7 transcripts (splice variants), 196 orthologues, 18 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 26.4) and thyroid (RPKM 5.7).

Summary

Predicted to enable RNA binding activity. Involved in spermatogenesis. Located in cytoplasm and nucleus. Implicated in spermatogenic failure 30. [provided by Alliance of Genome Resources, Apr 2022]

TDRD9 Products (1)

mRNA	Protein	Name
NM_153046.3	NP_694591.2	ATP-dependent RNA helicase TDRD9

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28536242	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28536242	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28536242	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDRD9 Protein Structure

DEAD

Helicase_C

HA2

TUDOR

0
300
600
900
1200
1382 a.a.

Protein Preferred Names	Protein Names
ATP-dependent RNA helicase TDRD9	hypoxia-inducible HIG-1

Related Diseases

Diseases	Alias
Spermatogenic Failure 30	SPGF30
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spermatogenic Failure, Y-Linked, 2	SPGFY2 Spermatogenic Failure, Nonobstructive, Y-Linked Y-Linked Spermatogenic Failure 2 Azoospermia, Nonobstructive, Y-Linked Oligozoospermia, Nonobstructive, Y-Linked Oligospermia, Nonobstructive, Y-Linked Spermatogenic Arrest, Y-Linked Nonobstructive Y-Linked Spermatogenic Failure Spermatogenic Failure Y-Linked 2 Azoospermia Non-Obstructive Y-Linked Non-Obstructive Azoospermia And Infertility Oligospermia Non-Obstructive Y-Linked Oligozoospermia Non-Obstructive Y-Linked Spermatogenic Arrest Y-Linked Spermatogenic Failure Nonobstructive Y-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14339	TDRD9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22852	Tdrd9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29366	Tdrd9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TDRD9	VGNC	VGNC:99264
Felis catus	TDRD9	VGNC	VGNC:66051
Rattus norvegicus	TDRD9	RGD	RGD:1306942
Bos taurus	TDRD9	VGNC	VGNC:35722
Canis familiaris	TDRD9	VGNC	VGNC:47226
Mus musculus	TDRD9	MGD	MGI:1921941