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CNGA2 - cyclic nucleotide gated channel subunit alpha 2 Gene

Also Known as CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1260

About CNGA2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,734,746-151,745,564 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues, 17 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

CNGA2 Products (1)

mRNA	Protein	Name
NM_005140.3	NP_005131.1	cyclic nucleotide-gated olfactory channel

CNGA2 Protein Structure

Ion_trans

cNMP_binding

0
200
400
600
664 a.a.

Protein Preferred Names	Protein Names
cyclic nucleotide-gated olfactory channel	CNG channel alpha-2

Related Diseases

Diseases	Alias
Anosmia, Isolated Congenital	ANIC Isolated Congenital Anosmia Anosmia, Congenital Congenital Anosmia
Retinitis Pigmentosa 45	RP45 Retinitis Pigmentosa, Type 45
Achromatopsia 2	ACHM2 Rod Monochromatism 2 Rod Monochromacy 2 Rmch2 Colorblindness, Total Complete Achromatopsia Total Colorblindness Achromatopsia-2 Achromatopsia, Type 2 Color Blindness Achromatopsia
Seckel Syndrome 7	SCKL7 Microcephalic Primordial Dwarfism, Dauber Type Seckel Syndrome, Type 7
Orofaciodigital Syndrome Ix	OFD9 Orofaciodigital Syndrome With Retinal Abnormalities Oral-Facial-Digital Syndrome With Retinal Abnormalities Orofaciodigital Syndrome 9 Oral-Facial-Digital Syndrome Type 9 Ofds Ix Oral-Facial-Digital Syndrome, Type Ix Ofd Syndrome 9 Ofds 9 Oral Facial Digital Syndrome 9 Oral Facial Digital Syndrome Type 9 Orofaciodigital Syndrome Type 9 Orofaciodigital Syndrome, Type Ix
Retinitis Pigmentosa 83	RP83 Retinitis Pigmentosa, Type 83
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116540	L 858051	Activator	/	Unkown
HY-116540A	L 858051 dihydrochloride	Activator	/	Unkown
HY-RS02880	CNGA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175080	8-DY547-cGMP		/	Unkown
HY-RS22448	Cnga2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CNGA2	RGD	RGD:2367
Canis familiaris	CNGA2	VGNC	VGNC:39396
Bos taurus	CNGA2	VGNC	VGNC:27498
Felis catus	CNGA2	VGNC	VGNC:61012
Mus musculus	CNGA2	MGD	MGI:108040