TPRA1 - transmembrane protein adipocyte associated 1 Gene

Also Known as GPR175; TPRA40; TMEM227

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 131601

About TPRA1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,571,232-127,598,231 (from NCBI)

This gene has 12 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in placenta (RPKM 7.3), endometrium (RPKM 6.7) and 25 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TPRA1 Products (9)

mRNA Protein Name
NM_001136053.4 NP_001129525.1 transmembrane protein adipocyte-associated 1 isoform 1
NM_001142646.4 NP_001136118.1 transmembrane protein adipocyte-associated 1 isoform 2
NM_001353001.2 NP_001339930.1 transmembrane protein adipocyte-associated 1 isoform 1
NM_001353002.2 NP_001339931.1 transmembrane protein adipocyte-associated 1 isoform 1
NM_001353003.2 NP_001339932.1 transmembrane protein adipocyte-associated 1 isoform 1
NM_001353004.2 NP_001339933.1 transmembrane protein adipocyte-associated 1 isoform 1
NM_001353005.2 NP_001339934.1 transmembrane protein adipocyte-associated 1 isoform 1
NM_001353006.2 NP_001339935.1 transmembrane protein adipocyte-associated 1 isoform 3
NM_001353007.2 NP_001339936.1 transmembrane protein adipocyte-associated 1 isoform 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25464930 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPRA1 Protein Structure

Tmemb_40

Tmemb_40: Predicted membrane protein (35 - 312)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

transmembrane protein adipocyte-associated 1

  • G protein-coupled receptor 175

TPRA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TPRA1 Q86W33 NLGN3 Homo sapiens Q9NZ94-2
Anti Tag CoIP
25464930
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fox-Fordyce Disease

  • Fox Fordyce Disease

  • Apocrine Miliaria

  • Fox-Fordyce Syndrome

  • Miliaria, Apocrine
Dyschromatosis Universalis Hereditaria

  • Duh
Atrophic Rhinitis

  • Rhinitis, Atrophic

  • Ozena

  • Rhinitis Sicca

  • Dry Rhinitis

  • Ozaena
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14947 TPRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TPRA1 VGNC VGNC:79848
Mus musculus TPRA1 MGD MGI:1345190
Felis catus TPRA1 VGNC VGNC:66484
Canis familiaris TPRA1 VGNC VGNC:47752
Rattus norvegicus TPRA1 RGD RGD:620858
Bos taurus TPRA1 VGNC VGNC:54506
Others TPRA1 NCBI