SLC31A1 - solute carrier family 31 member 1 Gene

Also Known as CTR1; COPT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1317

About SLC31A1

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,221,544-113,264,492 (from NCBI)

This gene has 2 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 33.0), duodenum (RPKM 22.8) and 25 other tissues.

Summary

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

SLC31A1 Products (1)

mRNA Protein Name
NM_001859.4 NP_001850.1 high affinity copper uptake protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IDA
IDA: Inferred from direct assay
26745413 GOA
enables copper ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
11734551 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16501047 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24837030 GOA
enables silver ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
20569931 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
35027734 GOA
involved in copper ion import IDA
IDA: Inferred from direct assay
16135512 GOA
involved in plasma membrane copper ion transport IDA
IDA: Inferred from direct assay
11734551 GOA
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
15326162 GOA
involved in silver ion transmembrane transport IDA
IDA: Inferred from direct assay
20569931 GOA
involved in vascular endothelial growth factor receptor-2 signaling pathway IMP
IMP: Inferred from mutant phenotype
35027734 GOA
involved in xenobiotic transport IDA
IDA: Inferred from direct assay
20451502 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
26945057 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11734551 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
26945057 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC31A1 Protein Structure

Ctr

Ctr: Ctr copper transporter family (43 - 175)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

high affinity copper uptake protein 1

  • copper transport 1 homolog

SLC31A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC31A1 O15431 SLC31A1 Homo sapiens O15431
GMS
16501047
Intra
SLC31A1 O15431 ABHD18 Homo sapiens Q0P651
Anti Tag CoIP
33961781
Intra
SLC31A1 O15431 SLC31A1 Homo sapiens O15431
GMS
19240214
Intra
SLC31A1 O15431 SLC31A1 Homo sapiens O15431
3D-EM
19240214
Intra
SLC31A1 O15431 NCR3LG1 Homo sapiens Q68D85
Anti Tag CoIP
33961781
Intra
SLC31A1 O15431 SLC31A1 Homo sapiens O15431
3D-EM
16501047
Intra
SLC31A1 O15431 SLC31A1 Homo sapiens O15431
Crosslink
19240214
Intra
SLC31A1 O15431 SLC31A1 Homo sapiens O15431
Crosslink
16501047
Intra
SLC31A1 O15431 ABCB8 Homo sapiens Q9NUT2
Anti Tag CoIP
33961781
Intra
SLC31A1 O15431 ACAD10 Homo sapiens Q6JQN1
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLC31A1 Proteins

Cat. No. Product Name Accession Purity
HY-P72011 SLC31A1 Protein, Human (Cell-Free, His-SUMO) O15431 (M1-H190) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Wilson Disease

  • Hepatolenticular Degeneration

  • WD

  • Wilson'S Disease

  • WND

  • Westphal-Strumpell Syndrome

  • Copper Storage Disease

  • Cerebral Pseudosclerosis

  • Westphal Pseudosclerosis

  • Hepatolenticular Degeneration Syndrome

  • Copper Retention

  • Hepatocerebral Degeneration

  • Kinnier-Wilson Disease

  • Neurohepatic Degeneration

  • Progressive Hepatolenticular Degeneration

  • Lenticular Degenerative Disease

  • Wilson'S Syndrome

  • Lenticular Syndrome
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Menkes Disease

  • Copper Transport Disease

  • Menkes Syndrome

  • MNK

  • Kinky Hair Disease

  • Steely Hair Disease

  • Menkes Kinky-Hair Syndrome

  • Mk

  • Steely Hair Syndrome

  • Menkea Syndrome

  • Md

  • Menkes Kinky Hair Syndrome

  • Hypocupremia, Congenital

  • Kinky Hair Syndrome

  • X-Linked Copper Deficiency

  • Menkes Kinky Hair Disease
Metal Metabolism Disorder

  • Metal Metabolism, Inborn Errors

  • Inborn Metal Metabolism Disorder
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10387 RSM3 95.73% Unkown
HY-P10387A RSM3 TFA 98.83% Unkown
HY-RS13188 SLC31A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17281 Slc31a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23736 Slc31a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC31A1 VGNC VGNC:77455
Mus musculus SLC31A1 MGD MGI:1333843
Canis familiaris SLC31A1 VGNC VGNC:51761
Rattus norvegicus SLC31A1 RGD RGD:620059
Bos taurus SLC31A1 VGNC VGNC:34813
Felis catus SLC31A1 VGNC VGNC:102981
Others SLC31A1 NCBI