CPB2 - carboxypeptidase B2 Gene

Homo sapiens

Also known as CPU; PCPB; TAFI

Gene ID: 1361 | Gene type: protein coding

About CPB2

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:46,053,186-46,105,033 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 8 paralogues. Restricted expression toward liver (RPKM 288.0).

Summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The Carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as Carboxypeptidase A (cleaving aliphatic residues) or Carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on Carboxypeptidase B substrates. After Thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

CPB2 Products(2)

mRNA	Protein	Name
NM_001278541.2	NP_001265470.1	carboxypeptidase B2 isoform 2 preproprotein
NM_001872.5	NP_001863.3	carboxypeptidase B2 isoform 1 preproprotein

CPB2 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

carboxypeptidase B2

carboxypeptidase B-like protein

Recombinant CPB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7735	Carboxypeptidase B2/CPB2 Protein, Human (HEK293, His)	Q96IY4 (F23-V423)	≥95%
HY-P75451	Carboxypeptidase B2/CPB2 Protein, Human (423a.a, HEK293, His)	Q96IY4 (M1-V423)	≥95%

Related Diseases

Diseases

Alias

Factor Xiii Deficiency

Hereditary Factor Xiii Deficiency Disease	Deficiency, Laki-Lorand Factor
Congenital Factor Xiii Deficiency	Fibrin Stabilizing Factor Deficiency
Deficiency, Factor Xiii	Factor Xiii Deficiency Disease
Deficiency Of Factor Xiii	Fibrin-Stabilizing Factor Deficiency
Factor Xiii Deficiency, Congenital

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency	Rosenthal Syndrome
Pta Deficiency	Hemophilia C
Rosenthal Factor Deficiency	F11 Deficiency
Congenital Factor Xi Deficiency	Hereditary Factor Xi Deficiency Disease
Haemophilia C	Factor Xi Deficiency, Autosomal Dominant
Rosenthal'S Disease	Factor 11 Deficiency
Factor Xi	Factor Xi Deficiency, Autosomal Recessive
Factor Xi Deficiency, Congenital	FA11D
Thromboplastin Antecedent Deficiency	Pta - [Plasma Thromboplastin Antecedent] Deficiency
Congenital Factor Xi Deficiency Disease	Rosenthal Disease

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Thrombosis

Thrombosis Of Blood Vessel

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Disseminated Intravascular Coagulation

Defibrination Syndrome	Dic
Diffuse Or Disseminated Intravascular Coagulation	Fibrinolytic Purpura
Consumption Coagulopathy	Diffuse Intravascular Coagulation
Dic - [Disseminated Intravascular Coagulation]	Disseminated Intravascular Coagulopathy
Fibrinolysis Nos	Thrombolytic Purpura

Thrombophilia

Hypercoagulability State

Coronary Stenosis

Coronary Artery Stenosis

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome	Hughes Syndrome
Familial Antiphospholipid Syndrome	Aps
Lupus Anticoagulant, Familial	Anti-Phospholipid Syndrome
Apls	Classic Apls
Classic Antiphospholipid Syndrome	Acromegaloid Facial Appearance Syndrome
Anticardiolipin Syndrome

Prostate Signet Ring Cell Adenocarcinoma

Prostate Signet Ring Cell Carcinoma	Signet Ring Cell Carcinoma Of Prostate
Acinar Prostate Adenocarcinoma, Signet Ring Variant

Gas Gangrene

Myonecrosis	Gas Bacillus Infection
Gas Gangrene Due To Clostridia	Clostridial Myonecrosis
Clostridial Cellulitis

Byssinosis

Flax-Dressers' Disease	Cotton Mill Fever
Stripper'S Asthma	Monday Morning Fever
Cotton Workers' Lung Disease	Cotton-Dust Asthma
Mill Fever	Lung Fibrosis With Byssinosis
Airway Disease Due To Cotton Dust	Respiratory Tract Disorder Due To Cotton Dust
Strippers' Disease	Flax-Dressers' Disorder
Strippers' Asthma

Post-Thrombotic Syndrome

Postphlebitic Syndrome	Postthrombotic Syndrome
Postphlebetic Syndrome With Inflammation	Postphlebetic Syndrome With Ulcer
Postphlebetic Syndrome With Ulcer And Inflammation	Venous Stress Disorder

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Budd-Chiari Syndrome

Hepatic Vein Thrombosis	Chiari Syndrome
BDCHS	Membranous Obstruction Of The Inferior Vena Cava
Budd-Chiari Syndrome, Somatic	Movc
Budd-Chiari Syndrome, Susceptibility To, Somatic	Budd-Chiari Syndrome, Susceptibility To
Membranous Obstruction Of Inferior Vena Cava	Hepatic Vein Block
Obstruction Of Hepatic Veins	Hepatic Vein Obstruction
Hepatic Venous Block

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03088	CPB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPB2	MGD	MGI:1891837
Bos taurus	CPB2	VGNC	VGNC:27646
Macaca mulatta	CPB2	VGNC	VGNC:71457
Canis familiaris	CPB2	VGNC	VGNC:39550
Felis catus	CPB2	VGNC	VGNC:61118
Rattus norvegicus	CPB2	RGD	RGD:71035
Others	CPB2	NCBI