CPB2 - carboxypeptidase B2 Gene

Also Known as CPU; PCPB; TAFI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1361

About CPB2

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:46,053,186-46,105,033 (from NCBI)

This gene has 4 transcripts (splice variants), 222 orthologues and 8 paralogues. Restricted expression toward liver (RPKM 288.0).

Summary

Carboxypeptidases are Enzymes that hydrolyze C-terminal peptide bonds. The Carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these Enzymes are referred to as Carboxypeptidase A (cleaving aliphatic residues) or Carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on Carboxypeptidase B substrates. After Thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

CPB2 Products (2)

mRNA	Protein	Name
NM_001278541.2	NP_001265470.1	carboxypeptidase B2 isoform 2 preproprotein
NM_001872.5	NP_001863.3	carboxypeptidase B2 isoform 1 preproprotein

CPB2 Protein Structure

Propep_M14

Peptidase_M14

0
100
200
300
400
423 a.a.

Protein Preferred Names	Protein Names
carboxypeptidase B2	carboxypeptidase B-like protein

Recombinant CPB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7735	Carboxypeptidase B2/CPB2 Protein, Human (HEK293, His)	Q96IY4 (F23-V423)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Factor Xiii Deficiency	Hereditary Factor Xiii Deficiency Disease Deficiency, Laki-Lorand Factor Congenital Factor Xiii Deficiency Fibrin Stabilizing Factor Deficiency Deficiency, Factor Xiii Factor Xiii Deficiency Disease Deficiency Of Factor Xiii Fibrin-Stabilizing Factor Deficiency Factor Xiii Deficiency, Congenital
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Thrombosis	Thrombosis Of Blood Vessel
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Thrombophilia	Hypercoagulability State
Coronary Stenosis	Coronary Artery Stenosis
Antiphospholipid Syndrome	Antiphospholipid Antibody Syndrome Hughes Syndrome Familial Antiphospholipid Syndrome Aps Lupus Anticoagulant, Familial Anti-Phospholipid Syndrome Apls Classic Apls Classic Antiphospholipid Syndrome Acromegaloid Facial Appearance Syndrome Anticardiolipin Syndrome
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Gas Gangrene	Myonecrosis Gas Bacillus Infection Gas Gangrene Due To Clostridia Clostridial Myonecrosis Clostridial Cellulitis
Byssinosis	Flax-Dressers' Disease Cotton Mill Fever Stripper'S Asthma Monday Morning Fever Cotton Workers' Lung Disease Cotton-Dust Asthma Mill Fever Lung Fibrosis With Byssinosis Airway Disease Due To Cotton Dust Respiratory Tract Disorder Due To Cotton Dust Strippers' Disease Flax-Dressers' Disorder Strippers' Asthma
Post-Thrombotic Syndrome	Postphlebitic Syndrome Postthrombotic Syndrome Postphlebetic Syndrome With Inflammation Postphlebetic Syndrome With Ulcer Postphlebetic Syndrome With Ulcer And Inflammation Venous Stress Disorder
Pulmonary Artery Disease	Abnormality Of The Pulmonary Artery
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163617	c-PB2(OH)2	Inhibitor	/	Unkown
HY-RS03088	CPB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17450	Cpb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23906	Cpb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPB2	MGD	MGI:1891837
Bos taurus	CPB2	VGNC	VGNC:27646
Macaca mulatta	CPB2	VGNC	VGNC:71457
Canis familiaris	CPB2	VGNC	VGNC:39550
Felis catus	CPB2	VGNC	VGNC:61118
Rattus norvegicus	CPB2	RGD	RGD:71035
Others	CPB2	NCBI