GPAT4 - glycerol-3-phosphate acyltransferase 4 Gene

Also Known as AGPAT6; LPAATZ; TSARG7; 1-AGPAT 6; LPAAT-zeta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 137964

About GPAT4

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,578,200-41,625,001 (from NCBI)

This gene has 11 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 10.2), adrenal (RPKM 10.1) and 25 other tissues.

Summary

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

GPAT4 Products (3)

mRNA Protein Name
NM_001363197.2 NP_001350126.1 glycerol-3-phosphate acyltransferase 4 isoform 1 precursor
NM_001363198.2 NP_001350127.1 glycerol-3-phosphate acyltransferase 4 isoform 2
NM_178819.4 NP_848934.1 glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
18238778 GOA
enables glycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
18238778 GOA
Biological Process GO Annotation Evidence References Source
involved in acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
18238778 GOA
involved in phosphatidylcholine biosynthetic process IDA
IDA: Inferred from direct assay
18238778 GOA
NOT involved in triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
18238778 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18238778 GOA
located in membrane IDA
IDA: Inferred from direct assay
18238778 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPAT4 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (229 - 351)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 456 a.a.
Protein Preferred Names Protein Names

glycerol-3-phosphate acyltransferase 4

  • 1-AGP acyltransferase 6

Related Diseases

Diseases Alias
Spastic Monoplegia

  • Monoplegic Infantile Cerebral Palsy

  • Spastic Monoplegic Cerebral Palsy

  • Infantile Monoplegic Cerebral Palsy

  • Cerebral Palsy Spastic Monoplegic

  • Spastic Monoplegia Cerebral Palsy
Complete Generalized Lipodystrophy
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1

  • Fetal Akinesia Deformation Sequence

  • Fads

  • Fetal Akinesia Sequence

  • FADS1

  • Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome Type 1

  • Fetal Akinesia Deformation Sequence Syndrome

  • Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

  • Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

  • Pena-Shokeir Syndrome, Type I

  • Foetal Akinesia Deformation Sequence Syndrome

  • Foetal Akinesia Sequence

  • Fetal Akinesia Deformation Sequence Syndrome 1

  • Pena-Shokeir Syndrome, Type 1

  • Pena Shokeir Syndrome, Type 1

  • Akinesia, Fetal, Deformation Sequence

  • Akinesia, Fetal, Deformation Sequence, Type 1

  • Pena-Shokeir Syndrome Type I
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05618 GPAT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPAT4 VGNC VGNC:62655
Rattus norvegicus GPAT4 RGD RGD:1310520
Canis familiaris GPAT4 VGNC VGNC:49765
Macaca mulatta GPAT4 VGNC VGNC:84002
Mus musculus GPAT4 MGD MGI:2142716
Others GPAT4 NCBI