GPAT4 - glycerol-3-phosphate acyltransferase 4 Gene

Homo sapiens

Also known as AGPAT6; LPAATZ; TSARG7; 1-AGPAT 6; LPAAT-zeta

Gene ID: 137964 | Gene type: protein coding

About GPAT4

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,578,200-41,625,001 (from NCBI)

This gene has 11 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 10.2), adrenal (RPKM 10.1) and 25 other tissues.

Summary

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

GPAT4 Products(3)

mRNA	Protein	Name
NM_001363197.2	NP_001350126.1	glycerol-3-phosphate acyltransferase 4 isoform 1 precursor
NM_001363198.2	NP_001350127.1	glycerol-3-phosphate acyltransferase 4 isoform 2
NM_178819.4	NP_848934.1	glycerol-3-phosphate acyltransferase 4 isoform 1 precursor

GPAT4 Protein Structure

Acyltransferase

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

glycerol-3-phosphate acyltransferase 4

1-AGP acyltransferase 6

Related Diseases

Diseases

Alias

Spastic Monoplegia

Monoplegic Infantile Cerebral Palsy	Spastic Monoplegic Cerebral Palsy
Infantile Monoplegic Cerebral Palsy	Cerebral Palsy Spastic Monoplegic
Spastic Monoplegia Cerebral Palsy

Complete Generalized Lipodystrophy

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05618	GPAT4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPAT4	VGNC	VGNC:62655
Rattus norvegicus	GPAT4	RGD	RGD:1310520
Canis familiaris	GPAT4	VGNC	VGNC:49765
Macaca mulatta	GPAT4	VGNC	VGNC:84002
Mus musculus	GPAT4	MGD	MGI:2142716
Others	GPAT4	NCBI

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