ADGRG4 - adhesion G protein-coupled receptor G4 Gene

Also Known as PGR17; GPR112; RP1-299I16

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 139378

About ADGRG4

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,300,963-136,416,890 (from NCBI)

This gene has 3 transcripts (splice variants), 68 orthologues and 42 paralogues. Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues.

Summary

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an Orphan Receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

ADGRG4 Products (1)

mRNA Protein Name
NM_153834.4 NP_722576.3 adhesion G-protein coupled receptor G4

ADGRG4 Protein Structure

Pentaxin

Pentaxin: Pentaxin family (41 - 210)

GPS

GPS: GPCR proteolysis site, GPS, motif (2683 - 2728)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (2743 - 2982)

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  • 2500
  • 3080 a.a.
Protein Preferred Names Protein Names

adhesion G-protein coupled receptor G4

  • G protein-coupled receptor 112

Related Diseases

Diseases Alias
Neuroendocrine Carcinoma

  • Neuroendocrine Cancer

  • Carcinoma Neuroendocrine

  • Carcinoma, Neuroendocrine
Martin-Probst Syndrome

  • Deafness-Intellectual Disability, Martin-Probst Type Syndrome

  • Martin-Probst Deafness-Mental Retardation Syndrome

  • Mental Retardation, X-Linked, Syndromic, Martin-Probst Type

  • MRXSMP

  • Deafness-Intellectual Disability Syndrome, Martin-Probst Type

  • Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type

  • X-Linked Deafness-Intellectual Disability Syndrome Syndrome

  • X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome
Polymicrogyria, Bilateral Frontoparietal

  • Bilateral Frontoparietal Polymicrogyria

  • BFPP

  • Cerebellar Ataxia With Neuronal Migration Defect
Spastic Diplegia

  • Diplegic Infantile Cerebral Palsy

  • Little'S Disease

  • Cerebral Palsy

  • Cerebral Spastic Infantile Paralysis

  • Infantile Diplegic Cerebral Palsy

  • Infantile Spastic Cerebral Palsy

  • Littles Disease

  • Spastic Cerebral Palsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175232 GL64 98.80% Unkown
HY-RS00357 ADGRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADGRG4 RGD RGD:1564057
Mus musculus ADGRG4 MGD MGI:2685213
Canis familiaris ADGRG4 VGNC VGNC:37646
Others ADGRG4 NCBI