ADGRG4 - adhesion G protein-coupled receptor G4 Gene

Homo sapiens

Also known as PGR17; GPR112; RP1-299I16

Gene ID: 139378 | Gene type: protein coding

About ADGRG4

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,300,963-136,416,890 (from NCBI)

This gene has 3 transcripts (splice variants), 68 orthologues and 42 paralogues. Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues.

Summary

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]

ADGRG4 Products(1)

mRNA	Protein	Name
NM_153834.4	NP_722576.3	adhesion G-protein coupled receptor G4

ADGRG4 Protein Structure

Pentaxin

GPS

7tm_2

0
500
1000
1500
2000
2500
3080 a.a.

Protein Preferred Names

Protein Names

adhesion G-protein coupled receptor G4

G protein-coupled receptor 112

Related Diseases

Diseases

Alias

Neuroendocrine Carcinoma

Neuroendocrine Cancer	Carcinoma Neuroendocrine
Carcinoma, Neuroendocrine

Martin-Probst Syndrome

Deafness-Intellectual Disability, Martin-Probst Type Syndrome	Martin-Probst Deafness-Mental Retardation Syndrome
Mental Retardation, X-Linked, Syndromic, Martin-Probst Type	MRXSMP
Deafness-Intellectual Disability Syndrome, Martin-Probst Type	Hearing Loss-Intellectual Disability Syndrome, Martin-Probst Type
X-Linked Deafness-Intellectual Disability Syndrome Syndrome	X-Linked Hearing Loss-Intellectual Disability Syndrome Syndrome

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Spastic Diplegia

Diplegic Infantile Cerebral Palsy	Little'S Disease
Cerebral Palsy	Cerebral Spastic Infantile Paralysis
Infantile Diplegic Cerebral Palsy	Infantile Spastic Cerebral Palsy
Littles Disease	Spastic Cerebral Palsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00357	ADGRG4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADGRG4	RGD	RGD:1564057
Mus musculus	ADGRG4	MGD	MGI:2685213
Canis familiaris	ADGRG4	VGNC	VGNC:37646

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