CRYGD - crystallin gamma D Gene

Also Known as CCP; PCC; CACA; CCA3; CRYG4; CTRCT4; cry-g-D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1421

About CRYGD

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:208,121,607-208,124,524 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 68 orthologues, 14 paralogues and is associated with 9 phenotypes. Biased expression in ovary (RPKM 6.8) and bone marrow (RPKM 0.8).

Summary

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]

CRYGD Products (1)

mRNA Protein Name
NM_006891.4 NP_008822.2 gamma-crystallin D

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8943244 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to reactive oxygen species IDA
IDA: Inferred from direct assay
8943244 GOA
involved in visual perception IMP
IMP: Inferred from mutant phenotype
9927684 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRYGD Protein Structure

Crystall

Crystall: Beta/Gamma crystallin (3 - 82)

Crystall

Crystall: Beta/Gamma crystallin (89 - 170)

  • 0
  • 100
  • 174 a.a.
Protein Preferred Names Protein Names

gamma-crystallin D

  • gamma crystallin 4

CRYGD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
CRYGD P07320 Cryaa Rattus norvegicus P24623
GMS
22289178
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cataract 4, Multiple Types

  • Cataract 4 Multiple Types

  • CTRCT4

  • Cca3

  • Pcc

  • Aculeiform Cataract

  • Cataract 4, Multiple Types, With Or Without Microcornea

  • Cataract, Crystalline Aculeiform

  • Caca

  • Cataract, Congenital, Cerulean Type, 3

  • Congenital Cataract Cerulean Type 3

  • Cataract Congenital Dominant Non Nuclear

  • Ccp

  • Cataract, Nonnuclear Polymorphic Congenital

  • Cataract, Punctate, Progressive Juvenile-Onset

  • Cataract 4 Multiple Types With Or Without Microcornea

  • Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

  • Cataract, Polymorphic Congenital

  • Congenital Cataract Blue Dot Type 3

  • Congenital Non-Nuclear Polymorphic Cataract

  • Crystalline Aculeiform Cataract

  • Punctate, Progressive Juvenile-Onset, Cataract

  • Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Cataract 29

  • CTRCT29

  • Cataract 29, Coralliform

  • Cataract 29 Coralliform

  • Coralliform Cataract
Cataract 7

  • Cca1

  • CTRCT7

  • Cerulean Cataract

  • Cataract 7, Cerulean Type

  • Cataract, Congenital, Cerulean Type, 1

  • Cerulean Type Cataract 7

  • Congenital Cerulean Type Cataract 1

  • Cataract, Congenital, Blue Dot Type 1

  • Cataract, Congenital, Cerulean Type 1

  • Blue-Dot Cataract
Cataract 30, Multiple Types

  • CTRCT30

  • Cataract 30, Pulverulent

  • Pulverulent Cataract

  • Coppock-Like Cataract

  • Dusty Cataract

  • Pulverulent Cataract 30

  • Cataract 30

  • Cataract, Pulverulent
Cataract Microcornea Syndrome

  • Microcornea Cataract Syndrome

  • Cataract-Microcornea Syndrome
Early-Onset Lamellar Cataract
Early-Onset Nuclear Cataract
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Nuclear Senile Cataract

  • Senile Nuclear Cataract

  • Senile Nuclear Sclerosis
Mature Cataract

  • Total Or Mature Cataract

  • Total, Mature Senile Cataract
Carnitine-Acylcarnitine Translocase Deficiency

  • Cact Deficiency

  • Carnitine Acylcarnitine Translocase Deficiency

  • CACTD

  • Carnitine-Acylcarnitine Carrier Deficiency
Senile Cataract
Nance-Horan Syndrome

  • NHS

  • Cataract-Dental Syndrome

  • Cataract, X-Linked, With Hutchinsonian Teeth

  • Mesiodens-Cataract Syndrome

  • Cataract X-Linked With Hutchinsonian Teeth

  • Cataract Dental Syndrome

  • Mesiodens Cataract Syndrome
Babesiosis

  • Babesiasis

  • Infection By Babesia

  • Piroplasmosis

  • Human Babesiosis

  • Babesia Parasite Infection

  • Piroplasma Infection
Leukocoria

  • Leucocoria
Presbyopia

  • Subnormal Accommodation

  • Accommodation Insufficiency Of Old Age
Deprivation Amblyopia

  • Disuse Amblyopia

  • Stimulus Deprivation Amblyopia
Amblyopia

  • Lazy Eye
Lens Disease

  • Lens Diseases
Aniridia 1

  • Aniridia

  • Congenital Aniridia

  • AN1

  • An

  • Cataract With Late-Onset Corneal Dystrophy

  • Aplasia Of Iris

  • Absent Iris

  • Irideremia

  • Aniridia Ii, Formerly

  • An2, Formerly

  • An2

  • Aniridia Type Ii

  • Aniridia, Type 1

  • An-1

  • Absence Of Iris

  • Agenesis Of Iris

  • Congenital Absence Of Iris

  • Hereditary Aniridia

  • Sporadic Aniridia
Anterior Segment Dysgenesis

  • Anterior Segment Developmental Anomaly

  • Anterior Segment Mesenchymal Dysgenesis

  • Corneal Opacification And Other Ocular Anomalies

  • Sclerocornea With Other Ocular Anomalies

  • Asmd

  • Asod

  • Anterior Segment Ocular Dysgenesis

  • Foxe3-Related Ocular Disorder

  • Familial Ocular Anterior Segment Mesenchymal Dysgenesis

  • Dysgenesis, Anterior Segment

  • Irido-Corneal Dysgenesis

  • Axenfeld-Rieger Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03215 CRYGD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CRYGD RGD RGD:2422
Mus musculus CRYGD MGD MGI:88524
Bos taurus CRYGD VGNC VGNC:55342
Others CRYGD NCBI