Ghrhr - growth hormone releasing hormone receptor Gene

Also Known as lit; Ghrfr; little

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14602

Summary

Enables growth hormone-releasing hormone receptor activity and peptide hormone binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within several processes, including gland development; positive regulation of growth hormone secretion; and regulation of signal transduction. Located in plasma membrane. Is integral component of membrane. Is expressed in alimentary system; brain; metanephros; and spinal cord. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Orthologous to human GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ghrhr Products (1)

mRNA Protein Name
NM_001003685.3 NP_001003685.2 growth hormone-releasing hormone receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth hormone-releasing hormone receptor activity IGI
IGI: Inferred from genetic interaction
8391647 MGI
enables growth hormone-releasing hormone receptor activity IMP
IMP: Inferred from mutant phenotype
10537133 MGI
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
11773624 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10537133 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenohypophysis development IMP
IMP: Inferred from mutant phenotype
1270792 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
1334535 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
3008329 MGI
acts upstream of or within cell maturation IMP
IMP: Inferred from mutant phenotype
2980124 MGI
acts upstream of or within cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
16513828 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
11371619 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
3008329 MGI
acts upstream of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
3008329 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
1270792 MGI
acts upstream of hormone secretion IMP
IMP: Inferred from mutant phenotype
7679139 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
1270792 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
15059953 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
11773624 MGI
acts upstream of or within positive regulation of growth hormone secretion IMP
IMP: Inferred from mutant phenotype
978118 MGI
acts upstream of or within positive regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
7679139 MGI
acts upstream of or within positive regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
15690087 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
1270792 MGI
acts upstream of or within regulation of insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
7390396 MGI
acts upstream of or within regulation of intracellular steroid hormone receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10459853 MGI
acts upstream of or within regulation of protein metabolic process IGI
IGI: Inferred from genetic interaction
7510770 MGI
acts upstream of or within somatotropin secreting cell development IMP
IMP: Inferred from mutant phenotype
6116352 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
10537133 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10537133 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth hormone-releasing hormone receptor

  • GHRH receptor

  • GRF receptor

  • GRFR

  • growth hormone-releasing factor receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0089A Human growth hormone-releasing factor TFA Activator 99.49% Unkown
HY-P0089 Human growth hormone-releasing factor Activator 98.72% Unkown
HY-P3594 [His1,Nle27] GHRF (1-32), amide, human Activator / Unkown
HY-RS05414 GHRHR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19006 Ghrhr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25495 Ghrhr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ghrhr NCBI NCBI:2692