FBXL16 - F-box and leucine rich repeat protein 16 Gene

Also Known as Fbl16; C16orf22; c380A1.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146330

About FBXL16

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:692,500-705,801 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 15 paralogues. Biased expression in brain (RPKM 76.4), testis (RPKM 4.8) and 1 other tissue.

Summary

Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL16 Products (1)

mRNA Protein Name
NM_153350.4 NP_699181.2 F-box/LRR-repeat protein 16

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
34818544 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL16 Protein Structure

LRR_6

LRR_6: Leucine Rich repeat (319 - 339)

LRR_6

LRR_6: Leucine Rich repeat (345 - 365)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 16

FBXL16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXL16 Q8N461 HIF1A Homo sapiens Q16665
PLA
34818544
Intra
FBXL16 Q8N461 HIF1A Homo sapiens Q16665
Anti Tag CoIP
34818544
Intra
FBXL16 Q8N461 HIF1A Homo sapiens Q16665
Pull Down
34818544
Intra
FBXL16 Q8N461 HIF1A Homo sapiens Q16665
Anti Bait CoIP
34818544
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04785 FBXL16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FBXL16 VGNC VGNC:81405
Canis familiaris FBXL16 VGNC VGNC:54023
Bos taurus FBXL16 VGNC VGNC:52773
Rattus norvegicus FBXL16 RGD RGD:1309127
Mus musculus FBXL16 MGD MGI:2448488
Felis catus FBXL16 VGNC VGNC:80572
Others FBXL16 NCBI