AIFM3 - apoptosis inducing factor mitochondria associated 3 Gene

Homo sapiens

Also known as AIFL

Gene ID: 150209 | Gene type: protein coding

About AIFM3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,965,172-20,981,358 (from NCBI)

This gene has 19 transcripts (splice variants), 194 orthologues and 7 paralogues. Biased expression in colon (RPKM 10.4), brain (RPKM 8.4) and 7 other tissues.

Summary

Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; flavin adenine dinucleotide binding activity; and metal ion binding activity. Involved in execution phase of Apoptosis. Located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

AIFM3 Products(4)

mRNA	Protein	Name
NM_001018060.3	NP_001018070.1	apoptosis-inducing factor 3 isoform 2
NM_001146288.2	NP_001139760.1	apoptosis-inducing factor 3 isoform 3
NM_001386814.1	NP_001373743.1	apoptosis-inducing factor 3 isoform 1
NM_144704.3	NP_653305.1	apoptosis-inducing factor 3 isoform 1

AIFM3 Protein Structure

Rieske

Pyr_redox_2

Pyr_redox

Reductase_C

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

apoptosis-inducing factor 3

apoptosis-inducing factor like

Related Diseases

Diseases

Alias

Heparin Cofactor Ii Deficiency

Thrombophilia Due To Heparin Cofactor Ii Deficiency	THPH10
Hcf Ii Deficiency	Hcf2 Deficiency
Thrombophilia 10 Due To Heparin Cofactor Ii Deficiency	Hcf 2 Deficiency
Thrombophilia Due To Heparin Cofactor 2 Deficiency	Thrombophilia, Due To Heparin Cofactor Ii Deficiency

Chromosome 6q24-Q25 Deletion Syndrome

Chromosome 6q25-Q25 Deletion Syndrome	6q25 Microdeletion Syndrome
Monosomy 6q25	Del(6)(Q25)

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00494	AIFM3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AIFM3	VGNC	VGNC:25763
Mus musculus	AIFM3	MGD	MGI:1919418
Macaca mulatta	AIFM3	VGNC	VGNC:69709
Rattus norvegicus	AIFM3	RGD	RGD:1306028
Canis familiaris	AIFM3	VGNC	VGNC:37739
Felis catus	AIFM3	VGNC	VGNC:59701

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