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AIFM3 - apoptosis inducing factor mitochondria associated 3 Gene

Also Known as AIFL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 150209

About AIFM3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,965,172-20,981,358 (from NCBI)

This gene has 19 transcripts (splice variants), 194 orthologues and 7 paralogues. Biased expression in colon (RPKM 10.4), brain (RPKM 8.4) and 7 other tissues.

Summary

Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; flavin adenine dinucleotide binding activity; and metal ion binding activity. Involved in execution phase of Apoptosis. Located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]

AIFM3 Products (4)

mRNA	Protein	Name
NM_001018060.3	NP_001018070.1	apoptosis-inducing factor 3 isoform 2
NM_001146288.2	NP_001139760.1	apoptosis-inducing factor 3 isoform 3
NM_001386814.1	NP_001373743.1	apoptosis-inducing factor 3 isoform 1
NM_144704.3	NP_653305.1	apoptosis-inducing factor 3 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	15764604	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15764604	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	15764604	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15764604	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	15764604	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIFM3 Protein Structure

Rieske

Pyr_redox_2

Pyr_redox

Reductase_C

0
100
200
300
400
500
605 a.a.

Protein Preferred Names	Protein Names
apoptosis-inducing factor 3	apoptosis-inducing factor like

Related Diseases

Diseases	Alias
Heparin Cofactor Ii Deficiency	Thrombophilia Due To Heparin Cofactor Ii Deficiency THPH10 Hcf Ii Deficiency Hcf2 Deficiency Thrombophilia 10 Due To Heparin Cofactor Ii Deficiency Hcf 2 Deficiency Thrombophilia Due To Heparin Cofactor 2 Deficiency Thrombophilia, Due To Heparin Cofactor Ii Deficiency
Chromosome 6q24-Q25 Deletion Syndrome	Chromosome 6q25-Q25 Deletion Syndrome 6q25 Microdeletion Syndrome Monosomy 6q25 Del(6)(Q25)
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00494	AIFM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AIFM3	VGNC	VGNC:25763
Mus musculus	AIFM3	MGD	MGI:1919418
Macaca mulatta	AIFM3	VGNC	VGNC:69709
Rattus norvegicus	AIFM3	RGD	RGD:1306028
Canis familiaris	AIFM3	VGNC	VGNC:37739
Felis catus	AIFM3	VGNC	VGNC:59701