NEK10 - NIMA related kinase 10 Gene

Also Known as CILD44

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 152110

About NEK10

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:27,106,484-27,369,383 (from NCBI)

This gene has 14 transcripts (splice variants), 172 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 2.8), brain (RPKM 0.3) and 6 other tissues.

Summary

Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2022]

NEK10 Products (13)

mRNA	Protein	Name
NM_001031741.5	NP_001026911.1	serine/threonine-protein kinase Nek10 isoform 1
NM_001304384.3	NP_001291313.1	serine/threonine-protein kinase Nek10 isoform 4
NM_001394963.1	NP_001381892.1	serine/threonine-protein kinase Nek10 isoform 5
NM_001394964.1	NP_001381893.1	serine/threonine-protein kinase Nek10 isoform 6
NM_001394965.1	NP_001381894.1	serine/threonine-protein kinase Nek10 isoform 7
NM_001394966.1	NP_001381895.1	serine/threonine-protein kinase Nek10 isoform 8
NM_001394967.1	NP_001381896.1	serine/threonine-protein kinase Nek10 isoform 9
NM_001394968.1	NP_001381897.1	serine/threonine-protein kinase Nek10 isoform 10
NM_001394969.1	NP_001381898.1	serine/threonine-protein kinase Nek10 isoform 11
NM_001394970.1	NP_001381899.1	serine/threonine-protein kinase Nek10 isoform 2
NM_001394971.1	NP_001381900.1	serine/threonine-protein kinase Nek10 isoform 7
NM_152534.6	NP_689747.3	serine/threonine-protein kinase Nek10 isoform 2
NM_199347.4	NP_955379.2	serine/threonine-protein kinase Nek10 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein kinase activity	IDA IDA: Inferred from direct assay	20956560	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mucociliary clearance	IMP IMP: Inferred from mutant phenotype	31959991	GOA
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	20956560	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	20956560	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	20956560	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20956560	GOA
involved in regulation of cell cycle G2/M phase transition	IMP IMP: Inferred from mutant phenotype	20956560	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein kinase complex	IDA IDA: Inferred from direct assay	20956560	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK10 Protein Structure

Pkinase

0
200
400
600
800
1000
1172 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Nek10	NIMA (never in mitosis gene a)- related kinase 10

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 44	CILD44 Ciliary Dyskinesia, Primary, 44, Without Situs Inversus Primary Ciliary Dyskinesia 44 Primary Ciliary Dyskinesia 44 Without Situs Inversus Ciliary Dyskinesia, Primary, 44 Without Situs Inversus
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Spinocerebellar Ataxia, Autosomal Recessive 16	Autosomal Recessive Spinocerebellar Ataxia 16 SCAR16 Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 16 Spinocerebellar Ataxia, Autosomal Recessive, 16 Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09191	NEK10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NEK10	MGD	MGI:2685128
Felis catus	NEK10	VGNC	VGNC:63769
Macaca mulatta	NEK10	VGNC	VGNC:83929
Rattus norvegicus	NEK10	RGD	RGD:1564342
Canis familiaris	NEK10	VGNC	VGNC:43730
Bos taurus	NEK10	VGNC	VGNC:31992
Others	NEK10	NCBI