CUX1 - cut like homeobox 1 Gene

Also Known as CDP; CUX; p75; CASP; CDP1; COY1; Clox; GDDI; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1523

About CUX1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,816,007-102,283,958 (from NCBI)

This gene has 23 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 110 phenotypes. Ubiquitous expression in endometrium (RPKM 11.3), thyroid (RPKM 8.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

CUX1 Products (7)

mRNA Protein Name
NM_001202543.2 NP_001189472.1 Homeobox protein cut-like 1 isoform d
NM_001202544.3 NP_001189473.1 protein CASP isoform e
NM_001202545.3 NP_001189474.1 protein CASP isoform f
NM_001202546.3 NP_001189475.1 protein CASP isoform g
NM_001913.5 NP_001904.2 protein CASP isoform b
NM_181500.4 NP_852477.1 protein CASP isoform c
NM_181552.4 NP_853530.2 Homeobox protein cut-like 1 isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15656993 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15656993 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUX1 Protein Structure

CUT

CUT: CUT domain (546 - 623)

CUT

CUT: CUT domain (936 - 1010)

CUT

CUT: CUT domain (1121 - 1199)

Homeobox

Homeobox: Homeobox domain (1245 - 1301)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1505 a.a.
Protein Preferred Names Protein Names

protein CASP

Homeobox protein cut-like 1

  • CCAAT displacement protein

CUX1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83439 Protein CASP Antibody (YA3184) WB, ICC/IF, FC, IP Human, Mouse, Rat
HY-P83439A Protein CASP Antibody (YA3184)(PBS only) WB, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Global Developmental Delay With Or Without Impaired Intellectual Development

  • GDDI
Autosomal Dominant Non-Syndromic Intellectual Disability
Leiomyoma

  • Leiomyomatous Neoplasm

  • Leiomyomatous Tumor

  • Leiomyomas

  • Fibroid Tumor

  • Uterine Fibroids
Leiomyoma, Uterine

  • Uterine Leiomyoma

  • Uterine Fibroid

  • Uterine Fibroids

  • Plexiform Leiomyoma

  • UL

  • Leiomyoma Of Corpus Uteri

  • Uterus Fibroma
Thyroid Gland Cancer

  • Thyroid Gland Carcinoma

  • Malignant Neoplasm Of Thyroid Gland

  • Malignant Tumour Of Thyroid Gland

  • Thyroid Neoplasm

  • Thyroid Neoplasms

  • Neoplasm Of Thyroid Gland

  • Thyroid Gland Neoplasm

  • Head And Neck Cancer, Thyroid

  • Neoplasm Of The Thyroid Gland

  • Cancer Of The Thyroid

  • Primary Malignant Neoplasm Of Thyroglossal Duct

  • Malignant Neoplasm Of Thyroglossal Duct

  • Primary Malignant Neoplasm Of Thyroid Gland

  • Thyroglossal Duct Cancer

  • Toxic Goitre Malignant Tumour

  • Cancerous Goitre
Uterine Corpus Endometrial Carcinoma
Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities
Thyroid Gland Medullary Carcinoma

  • Medullary Thyroid Carcinoma

  • Medullary Carcinoma Of The Thyroid Gland

  • Ultimobranchial Thyroid Tumor

  • Ultimobranchial Thyroid Tumour

  • Thyroid Cancer, Medullary
Multiple Endocrine Neoplasia, Type Iib

  • Multiple Endocrine Neoplasia Type 2b

  • MEN2B

  • Wagenmann-Froboese Syndrome

  • Multiple Endocrine Neoplasia Iib

  • Mucosal Neuroma Syndrome

  • Multiple Endocrine Neoplasia, Type 3

  • Multiple Endocrine Neoplasia, Type 2b

  • Men Iib

  • Neuromata, Mucosal, With Endocrine Tumors

  • Multiple Endocrine Neoplasia, Type Iii, Formerly

  • Men3, Formerly

  • Men Type Iib

  • Men 2b

  • Multiple Endocrine Neoplasia Type 3

  • Multiple Neoplasia 2b

  • Neoplasia, Endocrine, Multiple, Type Iib
Periventricular Nodular Heterotopia

  • Periventricular Heterotopia

  • Pvnh

  • Familial Nodular Heterotopia

  • Heterotopia, Periventricular

  • Periventricular Heterotopia, X-Linked
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03369 CUX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19592 Cux1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26088 Cux1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CUX1 RGD RGD:620618
Macaca mulatta CUX1 VGNC VGNC:81298
Canis familiaris CUX1 VGNC VGNC:39738
Felis catus CUX1 VGNC VGNC:107752
Bos taurus CUX1 VGNC VGNC:27839
Mus musculus CUX1 MGD MGI:88568