GBP6 - guanylate binding protein family member 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 163351

About GBP6

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,364,059-89,388,160 (from NCBI)

This gene has 1 transcript (splice variant), 281 orthologues and 10 paralogues. Restricted expression toward esophagus (RPKM 171.0).

Summary

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]

GBP6 Products (2)

mRNA Protein Name
NM_001320257.2 NP_001307186.1 guanylate-binding protein 6 isoform 2
NM_198460.3 NP_940862.2 guanylate-binding protein 6 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP6 Protein Structure

GBP

GBP: Guanylate-binding protein, N-terminal domain (18 - 281)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (283 - 579)

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  • 633 a.a.
Protein Preferred Names Protein Names

guanylate-binding protein 6

  • GBP-6

GBP6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GBP6 Q6ZN66 GBP7 Homo sapiens Q8N8V2
Anti Tag CoIP
33961781
Intra
GBP6 Q6ZN66 GBP7 Homo sapiens Q8N8V2
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 6

  • NS6

  • Noonan Syndrome, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05312 GBP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22181 Gbp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28703 Gbp6 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GBP6 RGD RGD:1561523
Canis familiaris GBP6 VGNC VGNC:41134
Macaca mulatta GBP6 VGNC VGNC:104705
Others GBP6 NCBI