Hectd1 - HECT domain E3 ubiquitin protein ligase 1 Gene

Also Known as opm; b2b327Clo; A630086P08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 207304

Summary

Enables ubiquitin protein Ligase activity. Acts upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein ubiquitination. Is expressed in several structures, including extraembryonic component; genitourinary system; heart; hemolymphoid system gland; and lung. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hectd1 Products (8)

mRNA Protein Name
NM_001405181.1 NP_001392110.1 E3 ubiquitin-protein ligase HECTD1 isoform 2
NM_001405182.1 NP_001392111.1 E3 ubiquitin-protein ligase HECTD1 isoform 3
NM_001405183.1 NP_001392112.1 E3 ubiquitin-protein ligase HECTD1 isoform 4
NM_001405184.1 NP_001392113.1 E3 ubiquitin-protein ligase HECTD1 isoform 5
NM_001405185.1 NP_001392114.1 E3 ubiquitin-protein ligase HECTD1 isoform 6
NM_001405186.1 NP_001392115.1 E3 ubiquitin-protein ligase HECTD1 isoform 7
NM_001405187.1 NP_001392116.1 E3 ubiquitin-protein ligase HECTD1 isoform 8
NM_144788.3 NP_659037.2 E3 ubiquitin-protein ligase HECTD1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22431752 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
22431752 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
24855001 MGI
acts upstream of or within heart valve development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
24855001 MGI
acts upstream of or within negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22431752 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
9636176 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
17442300 MGI
acts upstream of or within protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
22431752 MGI
acts upstream of or within protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
22431752 MGI
acts upstream of or within protein autoubiquitination IMP
IMP: Inferred from mutant phenotype
22431752 MGI
acts upstream of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22431752 MGI
acts upstream of or within spongiotrophoblast differentiation IMP
IMP: Inferred from mutant phenotype
24855001 MGI
acts upstream of or within trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
24855001 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HECTD1

  • HECT domain containing 1

  • HECT domain-containing protein 1

  • HECT-type E3 ubiquitin transferase HECTD1

  • protein open mind

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06107 HECTD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20554 Hectd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27063 Hectd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hectd1 NCBI NCBI:25831