2. Gene
  3. HECTD1 - HECT domain E3 ubiquitin protein ligase 1 Gene

HECTD1 - HECT domain E3 ubiquitin protein ligase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EULIR

Gene ID: 25831 | Gene type: protein coding

About HECTD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:31,100,117-31,207,793 (from NCBI)

This gene has 30 transcripts (splice variants), 212 orthologues and 24 paralogues. Ubiquitous expression in thyroid (RPKM 22.9), testis (RPKM 20.1) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

HECTD1 Products(2)

mRNA Protein Name
NM_001411010.1 NP_001397939.1 E3 ubiquitin-protein ligase HECTD1 isoform 2
NM_015382.4 NP_056197.3 E3 ubiquitin-protein ligase HECTD1 isoform 1

HECTD1 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (401 - 480)

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (1109 - 1239)

MIB_HERC2

MIB_HERC2: Mib_herc2 (1277 - 1336)

HECT

HECT: HECT-domain (ubiquitin-transferase) (2180 - 2610)

  • 0
  • 500
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  • 2000
  • 2610 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HECTD1

E3 ligase for inhibin receptor

Related Diseases

Diseases Alias
Diffuse Pulmonary Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06107 HECTD1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HECTD1 MGD MGI:2384768
Bos taurus HECTD1 VGNC VGNC:29800
Felis catus HECTD1 VGNC VGNC:62782
Macaca mulatta HECTD1 VGNC VGNC:73200
Canis familiaris HECTD1 VGNC VGNC:41642
Rattus norvegicus HECTD1 RGD RGD:1561653