HECTD1 - HECT domain E3 ubiquitin protein ligase 1 Gene

Also Known as EULIR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25831

About HECTD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:31,100,117-31,207,793 (from NCBI)

This gene has 30 transcripts (splice variants), 212 orthologues and 24 paralogues. Ubiquitous expression in thyroid (RPKM 22.9), testis (RPKM 20.1) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in anatomical structure development; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein K63-linked ubiquitination. Predicted to act upstream of or within several processes, including animal organ development; negative regulation of protein localization to plasma membrane; and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

HECTD1 Products (2)

mRNA Protein Name
NM_001411010.1 NP_001397939.1 E3 ubiquitin-protein ligase HECTD1 isoform 2
NM_015382.4 NP_056197.3 E3 ubiquitin-protein ligase HECTD1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12421765 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
33711283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HECTD1 Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (401 - 480)

Sad1_UNC

Sad1_UNC: Sad1 / UNC-like C-terminal (1109 - 1239)

MIB_HERC2

MIB_HERC2: Mib_herc2 (1277 - 1336)

HECT

HECT: HECT-domain (ubiquitin-transferase) (2180 - 2610)

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  • 2500
  • 2610 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HECTD1

  • E3 ligase for inhibin receptor

Related Diseases

Diseases Alias
Diffuse Pulmonary Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06107 HECTD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20554 Hectd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27063 Hectd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HECTD1 MGD MGI:2384768
Bos taurus HECTD1 VGNC VGNC:29800
Felis catus HECTD1 VGNC VGNC:62782
Macaca mulatta HECTD1 VGNC VGNC:73200
Canis familiaris HECTD1 VGNC VGNC:41642
Rattus norvegicus HECTD1 RGD RGD:1561653
Others HECTD1 NCBI