AMER2 - APC membrane recruitment protein 2 Gene

Homo sapiens

Also known as FAM123A

Gene ID: 219287 | Gene type: protein coding

About AMER2

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:25,161,679-25,172,288 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 2 paralogues. Restricted expression toward brain (RPKM 25.9).

Summary

Enables phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AMER2 Products(2)

mRNA	Protein	Name
NM_152704.4	NP_689917.2	APC membrane recruitment protein 2 isoform 1
NM_199138.2	NP_954589.1	APC membrane recruitment protein 2 isoform 2

AMER2 Protein Structure

WTX

0
200
400
600
671 a.a.

Protein Preferred Names

Protein Names

APC membrane recruitment protein 2

family with sequence similarity 123A

Related Diseases

Diseases

Alias

Osteopathia Striata With Cranial Sclerosis

Hyperostosis Generalisata With Striations	Robinow-Unger Syndrome
OSCS	Osteopathia Striata Cranial Sclerosis
Osteopathia Striata-Cranial Sclerosis Syndrome	Horan-Beighton Syndrome
Os-Cs	Osteopathia Striata - Cranial Sclerosis
Voorhoeve Disease	Osc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00650	AMER2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AMER2	RGD	RGD:1559605
Macaca mulatta	AMER2	VGNC	VGNC:69707
Mus musculus	AMER2	MGD	MGI:1919375
Bos taurus	AMER2	VGNC	VGNC:106638
Felis catus	AMER2	VGNC	VGNC:102157

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