TYSND1 - trypsin like peroxisomal matrix peptidase 1 Gene

Also Known as NET41

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 219743

About TYSND1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,137,981-70,146,700 (from NCBI)

This gene has 4 transcripts (splice variants) and 188 orthologues. Broad expression in testis (RPKM 9.5), skin (RPKM 5.4) and 25 other tissues.

Summary

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

TYSND1 Products (2)

mRNA	Protein	Name
NM_001040273.3	NP_001035363.1	peroxisomal leader peptide-processing protease isoform b
NM_173555.4	NP_775826.2	peroxisomal leader peptide-processing protease isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22002062	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	22002062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA
enables serine-type endopeptidase activity	EXP EXP: Inferred from Experiment	22002062	GOA
enables serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	22002062	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein processing	IMP IMP: Inferred from mutant phenotype	22002062	GOA
involved in proteolysis	IMP IMP: Inferred from mutant phenotype	22002062	GOA
involved in regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	22002062	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in peroxisome	IDA IDA: Inferred from direct assay	22002062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TYSND1 Protein Structure

Trypsin_2

0
100
200
300
400
500
566 a.a.

Protein Preferred Names	Protein Names
peroxisomal leader peptide-processing protease	peroxisomal cysteine endopeptidase

Related Diseases

Diseases	Alias
Peroxisomal Acyl-Coa Oxidase Deficiency	Pseudoneonatal Adrenoleukodystrophy Straight-Chain Acyl-Coa Oxidase Deficiency Pseudoadrenoleukodystrophy PSEUDO-NALD Pseudo-Neonatal Adrenoleukodystrophy Acyl-Coa Oxidase Deficiency Peroxisomal Acyl-Coenzyme A Oxidase Acyl-Coenzyme A Oxidase Deficiency Adrenoleukodystrophy, Pseudoneonatal Deficiency, Peroxisomal Acyl-Coa Oxidase
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Peroxisome Biogenesis Disorder 1b	Peroxisome Biogenesis Disorder Infantile Refsum Disease Infantile Phytanic Acid Storage Disease PBD1B Refsum Disease, Infantile Adrenoleukodystrophy, Autosomal Neonatal Ird Mild Pbd-Zsd Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Pbd-Zsd Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder Autosomal Neonatal Adrenoleukodystrophy Refsum Disease Infantile Peroxisome Biogenesis Disorders Peroxisome Biogenesis Disorder, Type 1b
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15311	TYSND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TYSND1	VGNC	VGNC:55998
Macaca mulatta	TYSND1	VGNC	VGNC:79722
Rattus norvegicus	TYSND1	RGD	RGD:1307354
Mus musculus	TYSND1	MGD	MGI:1919017
Others	TYSND1	NCBI