PPP1R35 - protein phosphatase 1 regulatory subunit 35 Gene

Also Known as C7orf47

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221908

About PPP1R35

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,435,282-100,436,698 (from NCBI)

This gene has 5 transcripts (splice variants) and 98 orthologues. Broad expression in testis (RPKM 18.3), spleen (RPKM 14.1) and 25 other tissues.

Summary

Predicted to enable Phosphatase binding activity and protein Phosphatase Inhibitor activity. Predicted to be involved in negative regulation of Phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]

PPP1R35 Products (2)

mRNA	Protein	Name
NM_001346938.2	NP_001333867.1	protein phosphatase 1 regulatory subunit 35 isoform 2
NM_145030.4	NP_659467.1	protein phosphatase 1 regulatory subunit 35 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30168418	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of centriole elongation	IMP IMP: Inferred from mutant phenotype	30168418	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	30168418	GOA
located in centrosome	IDA IDA: Inferred from direct assay	30168418	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R35 Protein Structure

PPP1R35_C

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
protein phosphatase 1 regulatory subunit 35	UPF0683 protein C7orf47

Related Diseases

Diseases	Alias
Bardet-Biedl Syndrome 1	BBS1 Bardet-Biedl Syndrome 1, Modifier Of Bardet-Biedl Syndrome BBS Bardet-Biedl Syndrome, Type 1 Laurence-Moon-Bardet-Biedl Syndrome
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10997	PPP1R35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP1R35	VGNC	VGNC:76331
Canis familiaris	PPP1R35	VGNC	VGNC:44893
Mus musculus	PPP1R35	MGD	MGI:1922853
Felis catus	PPP1R35	VGNC	VGNC:107810
Rattus norvegicus	PPP1R35	RGD	RGD:1584367
Others	PPP1R35	NCBI