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KIF21B - kinesin family member 21B Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23046

About KIF21B

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,969,390-201,023,714 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 41 paralogues. Biased expression in bone marrow (RPKM 12.6), brain (RPKM 10.5) and 11 other tissues.

Summary

This gene encodes a member of the Kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

KIF21B Products (4)

mRNA	Protein	Name
NM_001252100.2	NP_001239029.1	kinesin-like protein KIF21B isoform 1
NM_001252102.2	NP_001239031.1	kinesin-like protein KIF21B isoform 3
NM_001252103.2	NP_001239032.1	kinesin-like protein KIF21B isoform 4
NM_017596.4	NP_060066.2	kinesin-like protein KIF21B isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF21B Protein Structure

Kinesin

WD40

0
300
600
900
1200
1500
1637 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF21B

Related Diseases

Diseases	Alias
Third Cranial Nerve Disease	Disorder Of Oculomotor Nerve Oculomotor Nerve Disorder Oculomotor Nerve Paralysis Third Cranial Nerve Disorder
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07275	KIF21B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF21B	MGD	MGI:109234
Felis catus	KIF21B	VGNC	VGNC:63113
Rattus norvegicus	KIF21B	RGD	RGD:1306206
Macaca mulatta	KIF21B	VGNC	VGNC:73945
Bos taurus	KIF21B	VGNC	VGNC:59343
Canis familiaris	KIF21B	VGNC	VGNC:42397