Smyd5 - SET and MYND domain containing 5 Gene

Also Known as Rrg1; Rai15; NN8-4AG

Species: Mus musculus

Gene Type: protein coding
Gene ID: 232187

Summary

Enables Histone Methyltransferase activity (H4-K20 specific). Involved in several processes, including histone H4-K20 trimethylation; negative regulation of gene expression, epigenetic; and negative regulation of transposition. Is expressed in several structures, including alimentary system; brain; heart; skeletal musculature; and spleen. Orthologous to human SMYD5 (SMYD family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Smyd5 Products (1)

mRNA Protein Name
NM_144918.2 NP_659167.2 histone-lysine N-trimethyltransferase SMYD5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H4K20 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
22921934 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28250819 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
22921934 MGI
involved in regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
28250819 MGI
involved in regulation of stem cell division IMP
IMP: Inferred from mutant phenotype
28250819 MGI
involved in retrotransposon silencing by heterochromatin formation IMP
IMP: Inferred from mutant phenotype
28951459 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-trimethyltransferase SMYD5

  • SET and MYND domain-containing protein 5

  • [histone H4]-lysine20 N-trimethyltransferase SMYD5

  • retinoic acid induced 15

  • retinoic acid responsive gene 1

  • retinoic acid-induced protein 15

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13469 SMYD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21760 Smyd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smyd5 NCBI NCBI:10322