SMYD5 - SMYD family member 5 Gene

Also Known as RRG1; RAI15; NN8-4AG; ZMYND23

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10322

About SMYD5

Cytogenetic location: 2p13.2 Genomic coordinates (GRCh38): 2:73,214,245-73,227,221 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 8.4), testis (RPKM 6.1) and 25 other tissues.

Summary

Predicted to enable Histone Methyltransferase activity (H4-K20 specific). Involved in negative regulation of transposition and regulation of stem cell differentiation. [provided by Alliance of Genome Resources, Apr 2022]

SMYD5 Products (1)

mRNA Protein Name
NM_006062.3 NP_006053.2 histone-lysine N-trimethyltransferase SMYD5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
28951459 GOA
involved in retrotransposon silencing by heterochromatin formation IMP
IMP: Inferred from mutant phenotype
28951459 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMYD5 Protein Structure

SET

SET: SET domain (33 - 351)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

histone-lysine N-trimethyltransferase SMYD5

  • SET and MYND domain-containing protein 5

SMYD5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
SMYD5 Q6GMV2 Ppargc1a Mus musculus O70343
Methyltransferase Ass
35643234
Cross
SMYD5 Q6GMV2 Ppargc1a Mus musculus O70343
Anti Tag CoIP
35643234
Intra
SMYD5 Q6GMV2 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
SMYD5 Q6GMV2 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13469 SMYD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21760 Smyd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SMYD5 MGD MGI:108048
Macaca mulatta SMYD5 VGNC VGNC:77719
Rattus norvegicus SMYD5 RGD RGD:1309153
Canis familiaris SMYD5 VGNC VGNC:46583
Felis catus SMYD5 VGNC VGNC:65513
Bos taurus SMYD5 VGNC VGNC:35046
Others SMYD5 NCBI