country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

WWC1 - WW and C2 domain containing 1 Gene

Also Known as KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23286

About WWC1

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:168,291,645-168,472,303 (from NCBI)

This gene has 16 transcripts (splice variants), 218 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in salivary gland (RPKM 17.1), kidney (RPKM 16.5) and 17 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

WWC1 Products (3)

mRNA	Protein	Name
NM_001161661.2	NP_001155133.1	protein KIBRA isoform 1
NM_001161662.2	NP_001155134.1	protein KIBRA isoform 2
NM_015238.3	NP_056053.1	protein KIBRA isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	24682284	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	24682284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16684779	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	35429439	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16684779	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IDA IDA: Inferred from direct assay	18596123	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	35429439	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	24682284	GOA
involved in negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24682284	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	18190796	GOA
involved in regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	20159598	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16684779	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24682284	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16684779	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18596123	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	18190796	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWC1 Protein Structure

0
200
400
600
800
1000
1113 a.a.

Protein Preferred Names	Protein Names
protein KIBRA	HBeAg-binding protein 3

Related Diseases

Diseases	Alias
Memory Quantitative Trait Locus	MEMRYQTL Memory, Enhanced, Qtl
Neurofibromatosis, Type Ii	Neurofibromatosis 2 Neurofibromatosis, Type 2 NF2 Neurofibromatosis Type Ii Bilateral Acoustic Neurofibromatosis Banf Acn Central Neurofibromatosis Neurofibromatosis, Central Type Acoustic Schwannomas, Bilateral Acoustic Neurinoma, Bilateral Bilateral Acoustic Neurinoma Bilateral Acoustic Schwannomas Familial Acoustic Neuromas
Bjornstad Syndrome	BJS Pili Torti And Nerve Deafness Ptd Pili Torti-Deafness Syndrome Deafness-Pili Torti-Hypogonadism Syndrome Deafness And Pili Torti, Bjornstad Type Pili Torti-Sensorineural Hearing Loss Björnstad Syndrome Ptnd Hearing Loss-Pili Torti-Hypogonadism Syndrome Bjoernstad Syndrome
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15856	WWC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22361	Wwc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28883	Wwc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WWC1	VGNC	VGNC:48439
Felis catus	WWC1	VGNC	VGNC:67096
Bos taurus	WWC1	VGNC	VGNC:36974
Macaca mulatta	WWC1	VGNC	VGNC:79809
Rattus norvegicus	WWC1	RGD	RGD:1308329
Mus musculus	WWC1	MGD	MGI:2388637
Others	WWC1	NCBI