ICE1 - interactor of little elongation complex ELL subunit 1 Gene

Also Known as KIAA0947

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23379

About ICE1

Cytogenetic location: 5p15.32 Genomic coordinates (GRCh38): 5:5,422,677-5,490,220 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 7.5), brain (RPKM 7.4) and 25 other tissues.

Summary

Enables protein-macromolecule adaptor activity. Involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Located in Cajal body; histone locus body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ICE1 Products (1)

mRNA Protein Name
NM_015325.3 NP_056140.1 little elongation complex subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22195968 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
23932780 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
23932780 GOA
involved in positive regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
23932780 GOA
involved in positive regulation of transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
23932780 GOA
involved in snRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22195968 GOA
involved in snRNA transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
23932780 GOA
Cellular Component GO Annotation Evidence References Source
located in Cajal body IDA
IDA: Inferred from direct assay
22195968 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
22195968 GOA
located in histone locus body IDA
IDA: Inferred from direct assay
23932780 GOA
part of transcription elongation factor complex IDA
IDA: Inferred from direct assay
23932780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

little elongation complex subunit 1

  • interactor of little elongator complex ELL subunit 1

Related Diseases

Diseases Alias
Cri-Du-Chat Syndrome

  • 5p Deletion Syndrome

  • 5p Partial Monosomy Syndrome

  • Monosomy 5p

  • Cat Cry Syndrome

  • Chromosome 5p Deletion Syndrome

  • Cri Du Chat Syndrome

  • 5p- Syndrome

  • 5p Minus Syndrome

  • Chromosome 5p- Syndrome

  • Chromosome 5 Short Arm Deletion Syndrome

  • Chromosome 5p Deletion

  • Deletion 5p

  • Cri Du Chat

  • 5p Partial Deletion Syndrome

  • Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06517 ICE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N14670 Pentenocin A Inhibitor / Unkown
HY-N14672 Pentenocin B Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ICE1 RGD RGD:1309747
Canis familiaris ICE1 VGNC VGNC:41858
Mus musculus ICE1 MGD MGI:2385865
Bos taurus ICE1 VGNC VGNC:30026
Macaca mulatta ICE1 VGNC VGNC:73457
Felis catus ICE1 VGNC VGNC:62867
Others ICE1 NCBI