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CHST5 - carbohydrate sulfotransferase 5 Gene

Also Known as gn6st-3; hIGn6ST; I-GlcNAc6ST; glcNAc6ST-3; I-GlcNAc-6-ST

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23563

About CHST5

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,528,530-75,536,108 (from NCBI)

This gene has 2 transcripts (splice variants), 71 orthologues and 6 paralogues. Biased expression in colon (RPKM 16.2), duodenum (RPKM 16.2) and 2 other tissues.

Summary

The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]

CHST5 Products (1)

mRNA	Protein	Name
NM_024533.5	NP_078809.2	carbohydrate sulfotransferase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N-acetylglucosamine 6-O-sulfotransferase activity	IDA IDA: Inferred from direct assay	10491328	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-acetylglucosamine metabolic process	IDA IDA: Inferred from direct assay	10491328	GOA
involved in sulfur compound metabolic process	IDA IDA: Inferred from direct assay	10491328	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12855678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST5 Protein Structure

Sulfotransfer_1

0
100
200
300
411 a.a.

Protein Preferred Names	Protein Names
carbohydrate sulfotransferase 5	GST4-alpha

Related Diseases

Diseases	Alias
Macular Dystrophy, Corneal	Macular Corneal Dystrophy MCD Corneal Dystrophy, Macular Type Groenouw Type Ii Corneal Dystrophy Fehr Corneal Dystrophy Macular Dystrophy, Corneal Type 1 Mcdc1 Macular Corneal Dystrophy Type Ii Macular Corneal Dystrophy, Type Ii Macular Corneal Dystrophy, Type I Mcdc1, Formerly Macular Dystrophy, Corneal, 1 Macular Corneal Dystrophy Type 1 Corneal Dystrophy Groenouw Type Ii Corneal Dystrophy Macular Type Macular Corneal Dystrophy Type I Dystrophy, Macular, Corneal
Corneal Dystrophy, Groenouw Type I	CDGG1 Gcd1 Groenouw Corneal Dystrophy Type I Granular Corneal Dystrophy 1 Granular Corneal Dystrophy Type I Corneal Dystrophy Groenouw Type I Granular Corneal Dystrophy, Type I Corneal Dystrophy, Punctate Or Nodular Groenouw Type I Corneal Dystrophy Corneal Dystrophy Granular Type Corneal Dystrophy Punctate Or Nodular Classic Gcd Classic Granular Corneal Dystrophy Gcdi Granular Corneal Dystrophy Type 1 Corneal Dystrophy, Groenouw Type 1 Mesh D003317 Punctate Or Nodular Corneal Dystrophy Dystrophy, Corneal, Groenouw Type I
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 1	Xylosylprotein 4-Beta-Galactosyltransferase Deficiency Xgpt Deficiency EDSSPD1 Ehlers-Danlos Syndrome With Short Stature And Limb Anomalies Edssla Proteodermatan Sulfate, Defective Biosynthesis Of Pds, Defective Biosynthesis Of Dermatan Sulfate Proteoglycan Galactosyltransferase I Deficiency Ehlers-Danlos Syndrome Spondylodysplastic Type 1 Spondylodysplastic Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome, Progeroid Type, 1, Formerly Edsp1, Formerly Ehlers-Danlos Syndrome, Progeroid Type Galactosyltransferase 1 Deficiency Spondylodysplastic Eds Speds Defective Biosynthesis Of Pds Defective Biosynthesis Of Proteodermatan Sulfate Edsp1 Ehlers-Danlos Syndrome, Progeroid Type, 1 Proteodermatan Sulfate Defective Biosynthesis Of Ehlers-Danlos, Spondylodysplastic Syndrome Ehlers-Danlos Syndrome, Progeroid Form
Joubert Syndrome 20	JBTS20 Joubert Syndrome, Type 20
Blepharochalasis	Dermatolysis Palpebrarum Adiposa Ptosis
Stromal Dystrophy
Corneal Dystrophy, Lisch Epithelial	Lisch Epithelial Corneal Dystrophy LECD Band-Shaped And Whorled Microcystic Corneal Epithelial Dystrophy Band-Shaped And Whorled Microcystic Band-Shaped And Whorled Microcystic Dystrophy Of The Corneal Epithelium
Spondyloepiphyseal Dysplasia, Kimberley Type	SEDK Spondyloepiphyseal Dysplasia Kimberley Type Spondyloepiphyseal Dysplasia Type Kimberley Dysplasia, Spondyloepiphyseal, Kimberley Type
Granular Corneal Dystrophy	Granular Dystrophy Corneal Corneal Dystrophies, Hereditary Hereditary Corneal Dystrophy Corneal Dystrophy Nos Familial Hereditary Corneal Degeneration Hereditary Corneal Opacity
Sorsby Fundus Dystrophy	SFD Fundus Dystrophy, Pseudoinflammatory, Of Sorsby Sorsby'S Fundus Dystrophy Macular Dystrophy, Hemorrhagic Hemorrhagic Macular Dystrophy Pseudoinflammatory Fundus Dystrophy Of Sorsby Sorsby'S Pseudoinflammatory Macular Dystrophy Sorsby Pseudoinflammatory Fundus Dystrophy Dystrophy, Fundus, Sorsby

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02691	CHST5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19997	Chst5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHST5	MGD	MGI:1931825
Others	CHST5	NCBI