Sh2b2 - SH2B adaptor protein 2 Gene

Mus musculus

Also known as Aps

Gene ID: 23921 | Gene type: protein coding

About Sh2b2

Summary

Enables transmembrane receptor protein tyrosine kinase adaptor activity. Involved in intracellular signal transduction. Acts upstream of or within several processes, including B-1 B cell homeostasis; brown fat cell differentiation; and cell surface receptor signaling pathway. Located in actin filament; ruffle; and stress fiber. Is expressed in dorsal aorta. Orthologous to human SH2B2 (SH2B adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Sh2b2 Products(3)

mRNA	Protein	Name
NM_001302938.1	NP_001289867.1	SH2B adapter protein 2 isoform 1
NM_001302939.1	NP_001289868.1	SH2B adapter protein 2 isoform 2
NM_018825.4	NP_061295.2	SH2B adapter protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10196204	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	10872802	MGI
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA IDA: Inferred from direct assay	10196204	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	10872802	MGI
acts upstream of or within B-1 B cell homeostasis	IMP IMP: Inferred from mutant phenotype	14993264	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	14993264	MGI
acts upstream of or within actin cytoskeleton organization	IPI IPI: Inferred from physical interaction	15946664	MGI
acts upstream of or within brown fat cell differentiation	IDA IDA: Inferred from direct assay	18492766	MGI
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10872802	MGI
acts upstream of or within insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	10196204	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10872802	MGI
acts upstream of or within regulation of immune response	IMP IMP: Inferred from mutant phenotype	14993264	MGI
acts upstream of or within regulation of metabolic process	IMP IMP: Inferred from mutant phenotype	14578283	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin filament	IDA IDA: Inferred from direct assay	14993264	MGI
located in ruffle	IDA IDA: Inferred from direct assay	15946664	MGI
located in stress fiber	IDA IDA: Inferred from direct assay	15946664	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH2B adapter protein 2

SH2 and PH domain-containing adapter protein APS	adapter protein with pleckstrin homology and Src homology 2 domains
adaptor protein with pleckstrin homology and src homology 2 domains	insulin receptor substrate 5

Sh2b2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sh2b2	Q9JID9	Fgfr3	Mus musculus	Q61851	Lex-A Dimerization	11827956
Intra	Sh2b2	Q9JID9	Fgfr3	Mus musculus	Q61851	Y2H	11827956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12819	SH2B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh2b2	NCBI	NCBI:10603

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