Mrtfb - myocardin related transcription factor B Gene

Mus musculus

Also known as Mkl2; Gt4-1; MRTF-B; SOLOIST; mKIAA1243

Gene ID: 239719 | Gene type: protein coding

About Mrtfb

Summary

Enables DNA-binding transcription factor activity; actin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and smooth muscle cell differentiation. Located in cytoplasm. Is expressed in cardiovascular system; genitourinary system; liver; septum transversum; and yolk sac. Orthologous to human MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]

Mrtfb Products(3)

mRNA	Protein	Name
NM_001122667.2	NP_001116139.1	myocardin-related transcription factor B isoform 3
NM_153588.3	NP_705816.2	myocardin-related transcription factor B isoform 1
NM_181860.1	NP_862908.1	myocardin-related transcription factor B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17991879	MGI
enables actin binding	IDA IDA: Inferred from direct assay	15798203	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12397177	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12397177	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	16204380	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16204380	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within neuron projection development	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15798203	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17991879	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12397177	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17183527	MGI
acts upstream of or within vascular associated smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16204380	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15798203	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocardin-related transcription factor B

MKL/myocardin-like 2	MKL/myocardin-like protein 2
gene trap insertion site 4-1	megakaryoblastic leukemia 2
myocardial related transcription factor B

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08694	MRTFB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mrtfb	NCBI	NCBI:57496

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