Mrtfb - myocardin related transcription factor B Gene

Also Known as Mkl2; Gt4-1; MRTF-B; SOLOIST; mKIAA1243

Species: Mus musculus

Gene Type: protein coding
Gene ID: 239719

Summary

Enables DNA-binding transcription factor activity; actin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and smooth muscle cell differentiation. Located in cytoplasm. Is expressed in cardiovascular system; genitourinary system; liver; septum transversum; and yolk sac. Orthologous to human MRTFB (myocardin related transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]

Mrtfb Products (3)

mRNA Protein Name
NM_001122667.2 NP_001116139.1 myocardin-related transcription factor B isoform 3
NM_153588.3 NP_705816.2 myocardin-related transcription factor B isoform 1
NM_181860.1 NP_862908.1 myocardin-related transcription factor B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17991879 MGI
enables actin binding IDA
IDA: Inferred from direct assay
15798203 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12397177 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12397177 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
16204380 MGI
acts upstream of or within cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16204380 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within neuron projection development IGI
IGI: Inferred from genetic interaction
20534669 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15798203 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17991879 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12397177 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17183527 MGI
acts upstream of or within vascular associated smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
16204380 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15798203 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myocardin-related transcription factor B

  • MKL/myocardin-like 2

  • MKL/myocardin-like protein 2

  • gene trap insertion site 4-1

  • megakaryoblastic leukemia 2

  • myocardial related transcription factor B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08694 MRTFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mrtfb NCBI NCBI:57496