MRTFB - myocardin related transcription factor B Gene

Also Known as MKL2; MRTF-B; NPD001

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57496

About MRTFB

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:13,994,774-14,266,779 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.0), testis (RPKM 5.1) and 24 other tissues.

Summary

Enables transcription coactivator activity. Involved in positive regulation of pri-miRNA transcription by RNA polymerase II and positive regulation of striated muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MRTFB Products (13)

mRNA Protein Name
NM_001308142.2 NP_001295071.1 myocardin-related transcription factor B isoform 1
NM_001365411.2 NP_001352340.1 myocardin-related transcription factor B isoform 3
NM_001365412.2 NP_001352341.1 myocardin-related transcription factor B isoform 4
NM_001365413.2 NP_001352342.1 myocardin-related transcription factor B isoform 5
NM_001365414.2 NP_001352343.1 myocardin-related transcription factor B isoform 6
NM_001365415.2 NP_001352344.1 myocardin-related transcription factor B isoform 7
NM_001365416.2 NP_001352345.1 myocardin-related transcription factor B isoform 8
NM_001365417.3 NP_001352346.1 myocardin-related transcription factor B isoform 9
NM_001365418.3 NP_001352347.1 myocardin-related transcription factor B isoform 9
NM_001365419.3 NP_001352348.1 myocardin-related transcription factor B isoform 9
NM_001365420.3 NP_001352349.1 myocardin-related transcription factor B isoform 9
NM_001365421.3 NP_001352350.1 myocardin-related transcription factor B isoform 9
NM_014048.4 NP_054767.3 myocardin-related transcription factor B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12397177 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
14565952 GOA
enables transcription coactivator activity IGI
IGI: Inferred from genetic interaction
23764775 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of miRNA transcription IGI
IGI: Inferred from genetic interaction
23764775 GOA
involved in positive regulation of striated muscle tissue development IDA
IDA: Inferred from direct assay
14565952 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14565952 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRTFB Protein Structure

RPEL

RPEL: RPEL repeat (51 - 74)

RPEL

RPEL: RPEL repeat (95 - 119)

RPEL

RPEL: RPEL repeat (139 - 163)

SAP

SAP: SAP domain (401 - 433)

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  • 1000
  • 1049 a.a.
Protein Preferred Names Protein Names

myocardin-related transcription factor B

  • CTA-276F8.1

MRTFB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MRTFB Q9ULH7 SRF Homo sapiens P11831
Affinity Techniques
14565952
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chondroid Lipoma
Spondylometaphyseal Dysplasia, Sedaghatian Type

  • SMDS

  • Sedaghatian Chondrodysplasia

  • Spondylometaphyseal Dysplasia Sedaghatian Type

  • Congenital Lethal Metaphyseal Chondrodysplasia

  • Metaphyseal Chondrodysplasia, Congenital Lethal

  • Lethal Metaphyseal Dysplasia
Schizophrenia 12

  • Sczd12

  • Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Left Ventricular Noncompaction

  • Noncompaction Cardiomyopathy

  • Left Ventricular Hypertrabeculation

  • Lvnc

  • Spongy Myocardium

  • Isolated Noncompaction Of The Ventricular Myocardium

  • Left Ventricular Myocardial Noncompaction Cardiomyopathy

  • Fetal Myocardium

  • Honeycomb Myocardium

  • Hypertrabeculation Syndrome

  • Left Ventricular Non-Compaction

  • Lvht

  • Non-Compaction Of The Left Ventricular Myocardium

  • Ventricular Noncompaction, Left

  • Non-Compaction Cardiomyopathy
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08694 MRTFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MRTFB VGNC VGNC:31489
Felis catus MRTFB VGNC VGNC:63628
Canis familiaris MRTFB VGNC VGNC:43249
Mus musculus MRTFB MGD MGI:3050795
Rattus norvegicus MRTFB RGD RGD:1560833
Macaca mulatta MRTFB VGNC VGNC:74865
Others MRTFB NCBI